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DNA聚合酶、显色剂、标准阳性模板以及dd H2O。本发明的试剂盒具有敏感性高、特异性强、反应迅速、操作简单等特点，不需要特殊的仪器设备，解决了弓形虫病检测时间长、工作量大、操作复杂等缺陷。可以用于检测临床样本是否携带弓形虫，以及弓形虫病的早期诊断和分子流行病学调查。","2011.02.16#公开;2011.03.30#实质审查的生效;2012.08.01#授权","CN201010526397.X","C12Q1\u002F68","张德林;王萌;王艳华;付宝权;李文卉",[],[],{"resultType":8,"id":90,"title":91,"abstract":92,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":93,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":94,"ipc":95,"inventors":96,"tags":97,"tagNames":98},"gpi_01927","一种检测羊无浆体病原的环介导恒温扩增方法","本发明公开一种用于检测羊无浆体病原的环介导恒温扩增(LAMP)方法。以羊无浆体主要表面蛋白4基因为靶基因，设计了3对特异性引物，并按一定比例配制成特异性引物反应混合物，在恒温条件下进行DNA扩增。不需要复杂的仪器如PCR扩增仪，只需要常规的水浴锅就可以完成检测，并具有快速、敏感、高特异性和操作简单的特点，在常规的实验室就可以进行该病原的检测。因此，其适合于羊无浆体病原的检测和大规模的流行病学调查，而且可得到具有高敏感性的检测结果。","2011.03.16#公开;2011.05.04#实质审查的生效;2012.09.26#著录事项变更;2012.10.17#授权","CN201010542863.3","C12Q1\u002F68;C12Q1\u002F04","殷宏;罗建勋;马朱玲;刘志杰;杨志飞;关贵全;李有爱;刘爱红;任乔云;刘军龙;牛庆丽",[],[],{"resultType":8,"id":100,"title":101,"abstract":102,"orgName":103,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":104,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":105,"ipc":106,"inventors":107,"tags":108,"tagNames":109},"gpi_01017","一种治疗乳腺增生病的中成药及其制备工艺","本发明涉及一种治疗乳腺增生病的中成药，该方药由下述原料重量份组成：柴胡10～30、当归10～30、赤芍10～30、丹参15～45、橘核9～27、王不留行9～27、海藻10～30、昆布10～30、制香附9～27、制没药5～20、制乳香5～20、鹿角霜15～40，以理气、活血、止痛、软坚、散结、调补冲任立法，达到标本兼治之功效。同时本发明还公开了该方药的制备方法。","甘肃省医学科学研究院","2010.02.10#公开;2010.04.14#实质审查的生效;2011.02.16#授权","CN200910117431.5","A61K36\u002F8905;A61P15\u002F14;A61K35\u002F32","石晓峰;范彬;沈薇;张芳红;马趣环;刘元强",[],[],{"resultType":8,"id":111,"title":112,"abstract":113,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":114,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":115,"ipc":116,"inventors":117,"tags":118,"tagNames":119},"gpi_01829","一种猪口蹄疫苗用的复合分子型佐剂及其制造方法","本发明涉及一种猪口蹄疫苗用的、由CpG基序和猪IFN-γ基因克隆入真核表达载体构成的佐剂及其制造方法，以及猪口蹄疫病毒灭活抗原疫苗与这种佐剂配伍而成猪口蹄疫苗组合物。本发明的这种复合分子型佐剂，其CpG基序为至少由3个GTCGTT、2个GACGTT和1个AACGTT特殊序列构成的一段基序，其序列为SEQ No：1，用其构建的PcDNA3.1重组质粒，并在大肠杆菌中增殖。","2011.01.26#公开;2011.03.23#实质审查的生效;2013.11.06#授权","CN201010297461.1","A61K39\u002F39;A61K39\u002F135;C12N15\u002F85;C12N15\u002F117;A61P31\u002F14","景志忠;陈国华;房永祥;窦永喜;蒙学莲;赵娜;曾爽;贾怀杰;才学鹏",[],[],{"resultType":8,"id":121,"title":122,"abstract":123,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":124,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":125,"ipc":126,"inventors":127,"tags":128,"tagNames":129},"gpi_00375","一种猪囊尾蚴病间接ELISA检测试剂盒及其制备方法","本发明提供了一种检测猪囊尾蚴抗体的间接ELISA试剂盒及其制备方法与应用。该试剂盒包括以基因工程表达的猪囊尾蚴TS－CC18蛋白作为包被抗原的ELISA板条，PBST洗液，血清稀释液，辣根过氧化物酶标记的兔抗猪IgG、显色底物、终止液及猪囊尾蚴标准阴阳性血清等。所用的重组抗原的制备是将编码猪囊尾蚴TS－CC18基因的片断与表达载体PET28a(+)连接，并转化大肠杆菌BL21(DE3)进行诱导表达；表达蛋白经镍柱亲和纯化后包被酶标板。本发明的优势体现在具有良好的特异性和敏感性、检测成本低廉、操作简单、可大量生产以及生产周期短等优点，有着良好的推广应用价值。","2008.11.12#公开;2009.01.07#实质审查的生效;2012.06.27#授权","CN200810108465.3","G01N33\u002F53","才学鹏;张少华;景志忠;骆学农;郭爱疆;郑亚东;贾万忠;窦永喜",[],[],{"resultType":8,"id":131,"title":132,"abstract":133,"orgName":134,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":135,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":136,"ipc":137,"inventors":138,"tags":139,"tagNames":140},"gpi_00849","一种生长抑素的合成方法","本发明涉及生长抑素的一种液相合成方法，其合成方法为：首先分别全合成Thr(Bzl)－Phe－Thr(Bzl)－Ser(Bzl)－Cys(MeOBzl)－OBzl、Boc－Phe－Trp－Lys(Z)－OH、Boc－Asn－Phe－OH和Boc－Ala－Gly－Cys(MeOBzl)－Lys(Z)－OH四4个片段肽，再用EDCI\u002FHOBt进行片段缩合，合成全保护的还原性十四肽，用三氟甲磺酸和苯甲醚系统脱肽链所有的保护基，得到还原性生长抑素，对还原性生长抑素氧化，获得生长抑素粗品，再经C18制备柱分离纯化，冷冻干燥后，得生长抑素。","兰州大学;甘肃中科药源生物工程股份有限公司","2009.11.04#公开;2012.05.09#实质审查的生效;2013.07.10#授权","CN200910142420.2","C07K7\u002F08;C07K1\u002F06;C07K1\u002F02;A61P5\u002F02;A61P5\u002F08;A61P5\u002F48;A61P1\u002F04;A61P1\u002F18;A61P7\u002F04","达朝山;苏亚宁;洪满贵;保英明;曹福军",[],[],{"resultType":8,"id":142,"title":143,"abstract":144,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":145,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":146,"ipc":147,"inventors":148,"tags":149,"tagNames":150},"gpi_00644","一种用于检测猪繁殖与呼吸综合症病毒的试剂盒和检测方法","一种用于检测猪繁殖与呼吸综合症病毒的试剂盒和检测方法，所述试剂盒包含RNA酶抑制剂、AMV逆转录酶、Taq酶、无RNA酶水、One Step RNA PCR混合液、阴性对照以及序列SEQ ID NO：1至SEQ ID NO：6引物的混合物，所述检测包括使用所述试剂盒进行RT－PCR扩增的步骤。所述方法能快速、敏感、准确以及低成本地检测猪繁殖与呼吸综合征病毒。","2009.06.24#公开;2009.08.19#实质审查的生效;2013.02.20#授权","CN200810241706.1","C12Q1\u002F70;C12Q1\u002F68;C12N15\u002F11","刘湘涛;田宏;吴锦艳;尚佑军;尹双辉;靳野",[],[],{"resultType":8,"id":152,"title":153,"abstract":154,"orgName":155,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":156,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":157,"ipc":158,"inventors":159,"tags":160,"tagNames":161},"gpi_01938","一种菜籽油用咪唑盐类极压抗磨添加剂及其制备方法","本发明公开了一种菜籽油用咪唑盐类极压抗磨添加剂及其制备方法。添加剂的化学名称为二烷基二硫代磷酸咪唑盐离子液体。本发明以三氯甲烷作溶剂，将二烷基二硫代磷酸以及二烷基咪唑溴盐混合均匀，常温搅拌反应，然后用蒸馏水洗至水层为中性，除去溶剂，得到产物为浅黄色粘稠液体。添加剂具有较高热稳定性和优异的减摩抗磨性能，可以作为菜籽油添加剂使用。","中国科学院兰州化学物理研究所","2011.03.23#公开;2011.05.04#实质审查的生效;2012.12.12#授权","CN200910117411.8","C10M137\u002F10;C10M133\u002F46;C07F9\u002F17;C07D233\u002F58;C10N30\u002F06","刘维民;李金龙;周峰;夏延秋",[],[],{"resultType":8,"id":163,"title":164,"abstract":165,"orgName":166,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":167,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":168,"ipc":169,"inventors":170,"tags":171,"tagNames":172},"gpi_00872","一种锁阳多糖的制备方法","本发明公开了一种锁阳多糖的制备方法，包括如下步骤：在锁阳粉末中加入蒸馏水充分搅匀，浸泡24－36h后，补入蒸馏水，使料液比达到1\u002F26－1\u002F10，再进行超声波萃取，得到反应液；将所述反应液移至微波反应釜中，辅以机械搅拌，在40－80℃的温度条件、以及100－500W的功率条件下，反应20－60min后，进行过滤，得到上清液；对所述上清液依次进行浓缩处理、醇沉处理和离心处理，得到下沉沉淀，再对所述沉淀进行真空冷冻干燥处理，得到所述锁阳多糖。本发明所述制备方法，相比传统水提法，具有产率高、提取时间短和节约能耗的优点。","西北师范大学","2009.11.18#公开;2010.01.13#实质审查的生效;2012.03.21#授权","CN200910148024.0","C08B37\u002F00;A61P37\u002F04;A61P39\u002F06","张继;王风霞;刘忠旺;舒何晶;张兴晶;杨玉萍;张玉媛;徐小龙;梁俊玉;马君义;姚健",[],[],{"resultType":8,"id":174,"title":175,"abstract":176,"orgName":177,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":178,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":179,"ipc":180,"inventors":181,"tags":182,"tagNames":183},"gpi_01140","一种防治畜禽温热病药物组合物及其制备方法","本发明公开一种防治畜禽温热病药物组合物及其制备方法。以1500ml药液计算，药物含各味中药以生药材计算的量以及敷料量的配比为：连翘350～450g，板兰根150～250g，金银花150～250g，黄芩150～250g，黄连150～250g，鸭趾草150～250g，甘草75～125g，苯甲醇2-3g，其余为蒸馏水。药物组合物制备方法是采用水提、醇沉、药液配制三步骤制成注射剂。本发明通过大量的临床使用，证明该药物具有抗病毒、抗菌、消炎、清热解毒、增强免疫力功能，对以发热为主要特征的温病具有十分良好的治疗效果，其应用对于推动我国畜禽业的发展将产生积极作用。","中国农业科学院兰州畜牧与兽药研究所","2010.05.05#公开;2010.06.23#实质审查的生效;2011.11.30#授权","CN200910117622.1","A61K36\u002F718;A61P29\u002F00;A61P31\u002F04;A61P31\u002F14;A61P31\u002F16;A61P37\u002F04","李剑勇;张继瑜;李新圃;杨亚军;周绪正;牛建荣;魏小娟;李冰;陈佳娟",[],[],{"resultType":8,"id":185,"title":186,"abstract":187,"orgName":166,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":188,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":189,"ipc":190,"inventors":191,"tags":192,"tagNames":193},"gpi_00233","一种降低血糖产品的制备方法","一种降低血糖产品的制备方法；该方法是以锁阳为原料，通过粉碎、回流、抽滤、离心、酶解、萃取、减压浓缩、调节pH值、透析袋透析和离心等步骤，制备出一种主要用于治疗链脲佐菌素(STZ)造成的化学性糖尿病，并对糖尿病引起的肝脏、肾脏损伤具有明显修复作用的治疗药物产品。本发明充分利用甘肃、青海、内蒙古自治区境内遍布的寄生于蒺藜科白刺属植物的锁阳，且蕴藏量十分充足这一良好的资源优势，开发本产品，市场前景十分看好，经济效益广阔。","2008.07.16#公开;2008.09.10#实质审查的生效;2010.12.08#授权","CN200710187929.X","A61K36\u002F185;A61P3\u002F10","张继;吴依茜;王云普;王春霞;王俊龙;张亚楠;赵保堂",[],[],{"resultType":8,"id":195,"title":196,"abstract":197,"orgName":177,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":198,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":199,"ipc":200,"inventors":201,"tags":202,"tagNames":203},"gpi_00325","丁香酚阿斯匹林酯药用化合物及其制剂和制备方法","本发明公开一种丁香酚阿斯匹林酯药用化合物，结构如(I)式所示。它具有药理作用更为明显，结构更为稳定的特点。它是以阿斯匹林为原料，经酰氯化，在溶媒中进行酯化反应，经重结晶制得的化合物。以丁香酚阿斯匹林酯药用化合物为有效药用成分，可制成用于人医和兽医临床上治疗各种高热病症，尤其是病毒性感染所致、预防血栓形成、皮肤真菌感染的固体制剂、液体制剂、注射剂、眼用制剂、软膏剂、栓剂、膜剂、气雾剂或外用制剂。","2008.09.24#公开;2008.11.19#实质审查的生效;2010.06.09#授权","CN200810017950.X","C07C69\u002F86;C07C67\u002F08;A61K31\u002F621;A61P29\u002F00;A61P31\u002F00;A61P7\u002F02","李剑勇;张继瑜;周绪正;牛建荣;魏小娟",[],[],{"resultType":8,"id":205,"title":206,"abstract":207,"orgName":208,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":209,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":210,"ipc":211,"inventors":212,"tags":213,"tagNames":214},"gpi_00997","串级回旋加速器与双冷却储存环系统","本发明涉及一种串级回旋加速器与双冷却储存环系统。包括有离子源(500)和对称磁聚焦结构的冷却储存环(300)，对称磁聚焦结构的冷却储存环(300)注入端通过第一离子束输送线(600)与扇聚焦回旋加速器(100)或\u002F和分离扇聚焦回旋加速器(200)相接，对称磁聚焦结构的冷却储存环(300)引出端通过第二离子束输送线(700)与非对称磁聚焦结构的冷却储存环(400)相接。其采用一台或多台回旋加速器的级联组合、一个用于提高离子束流品质的带离子冷却技术装置的同步加速器储存环，同样也采用离子冷却技术装置的冷却储存环，有效满足高精度核物理试验及原子物理实验，并可应用于材料辐照、质子－重离子治癌等应用性研究项目。","中国科学院近代物理研究所","2010.01.20#公开;2010.03.24#实质审查的生效;2010.11.24#授权","CN200910000757.X","H05H13\u002F00;H05H13\u002F10;H05H7\u002F00;H05H7\u002F04","夏佳文;原有进",[],[],{"resultType":8,"id":216,"title":217,"abstract":218,"orgName":166,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":219,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":220,"ipc":221,"inventors":222,"tags":223,"tagNames":224},"gpi_00725","从马铃薯叶中提取纯化茄尼醇的方法","本发明公开了一种从马铃薯叶中提取纯化茄尼醇的方法。本发明以马铃薯叶为原料，通过微波辅助萃取、皂化、柱层析、结晶和重结晶等工艺，能得到纯度95％以上的茄尼醇制品。与现有工艺相比，本发明的方法具有选择性高，反应条件温和，工艺简单、生产周期短，批量大、茄尼醇收率和纯度高，便于产业化的特点。","2009.08.05#公开;2009.09.30#实质审查的生效;2011.08.10#授权","CN200910128487.0","C07C33\u002F02;C07C29\u002F86;C07C29\u002F78;C07C29\u002F76;A61P31\u002F00;A61P7\u002F04","张继;徐小龙;陈桐;马君义;姚健;梁俊玉;王云普;王俊龙;陶发琴",[],[],{"resultType":8,"id":226,"title":227,"abstract":228,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":229,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":230,"ipc":231,"inventors":232,"tags":233,"tagNames":234},"gpi_01867","区分莱姆病病原基因型的试剂及方法","本发明涉及一种用于区分莱姆病病原基因型的试剂和其使用方法。本发明的用于区分莱姆病病原基因型的试剂中至少有：狭义伯氏疏螺旋体LAMP特异性引物；嘎氏疏螺旋体LAMP特异性引物和伽氏疏螺旋体LAMP特异性引物；本发明的检测方法采用环介导的恒温扩增技术进行检测。","2011.02.09#公开;2011.06.22#实质审查的生效;2013.03.20#授权","CN200910258201.0","C12Q1\u002F68;C12R1\u002F01","殷宏;罗建勋;关贵全;牛庆丽;杨吉飞",[],[],{"resultType":8,"id":236,"title":237,"abstract":238,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":239,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":240,"ipc":241,"inventors":242,"tags":243,"tagNames":244},"gpi_00127","口蹄疫A型灭活疫苗","一种口蹄疫A型灭活疫苗，由A型口蹄疫病毒抗原和佐剂以抗原∶佐剂＝1∶1比例经：毒种、增殖病毒的程序、病毒灭活的程序、菌检、疫苗配制程序和疫苗检验步骤制备而成。本发明的安全性达国际同类产品先进水平；对A型口蹄疫的平均免疫效力为7.27PD50\u002F头份，超过了国际上战略应急疫苗的标准。因此，是高效的口蹄疫A型灭活疫苗，具有广阔的应用前景。免疫接种剂量缩减到了每头牛2mL，从而在不影响疫苗免疫效力的前提下，大大降低了疫苗的副反应，也降低了用于防疫的人力、物力和财力。","2008.02.27#公开;2008.04.23#实质审查的生效;2010.06.30#授权","CN200710018544.0","A61K39\u002F135;A61P31\u002F14","王永录;张永光;方玉珍;蒋守田;刘力宽;潘丽;吕建亮",[],[],{"resultType":8,"id":246,"title":247,"abstract":248,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":249,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":250,"ipc":251,"inventors":252,"tags":253,"tagNames":254},"gpi_00208","口蹄疫病毒双效疫苗载体、其制备方法及应用","本发明公开了一种口蹄疫病毒双效疫苗载体以及该双效疫苗载体的构建方法和用途。本发明口蹄疫病毒双效疫苗载体主要由双顺反子表达载体序列组成，其中含有能够与口蹄疫病毒基因组5’非编码区RNA结合的反义基因序列和完整的口蹄疫病毒VP1结构蛋白基因序列。动物试验表明，本发明口蹄疫病毒双效疫苗在动物口蹄疫的防制方面具有基因治疗及基因免疫双重功效。","2008.06.11#公开;2008.08.27#实质审查的生效;2009.12.23#授权","CN200710103083.7","C12N15\u002F63;A61K48\u002F00;A61P31\u002F12","柳纪省;杨彬;兰喜;殷相平;李学瑞;李宝玉;韩晓荣;李志勇;刘兆弼;方玉萍",[],[],{"resultType":8,"id":256,"title":257,"abstract":258,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":259,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":260,"ipc":261,"inventors":262,"tags":263,"tagNames":264},"gpi_00564","口蹄疫病毒多重RT－PCR检测试剂盒、其制备方法及应用","本发明公开了一种口蹄疫病毒多重RT－PCR检测试剂盒，其制备方法及应用，属于动物疫病检测领域。本发明试剂盒的正链扩增引物由引物1、引物2和引物3所示的核苷酸序列组成；所述的负链扩增引物由引物4、引物5和引物6所示的核苷酸序列组成。多重RT－PCR试剂盒具有较高的敏感性，较常规RT－PCR试剂盒的灵敏度高10～100倍，且具有很好的特异性，即使由于临床样品保存不当或采集时不新鲜时，口蹄疫病毒RNA因各种原因降解断裂，仍可以得到正确的结果，有效解决了病毒含量低微样品不易检出的问题，提高了诊断的可靠性，缩短了检测时间，减少了样品之间交叉污染的机会，检测结果更为准确、可靠。","2009.05.06#公开;2009.07.01#实质审查的生效;2011.08.31#授权","CN200710182090.0","C12Q1\u002F70;C12Q1\u002F68","刘在新;包慧芳;郭建宏;卢曾军;谢庆阁",[],[],{"resultType":8,"id":266,"title":267,"abstract":268,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":269,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":270,"ipc":271,"inventors":272,"tags":273,"tagNames":274},"gpi_01704","口蹄疫病毒样颗粒及制备方法和用途","本发明公开一种亚洲I型口蹄疫病毒样颗粒及制备方法和用途。本发明的亚洲I型口蹄疫病毒样颗粒是由亚洲I型口蹄疫病毒的结构蛋白VP0、VP3和VP1构成，其中VP0的基因序列为SEQ 1，其中VP3的基因序列为SEQ 3，其中VP1的基因序列为SEQ 2。本发明的亚洲I型口蹄疫病毒样颗粒制备方法是通过扩增得到结构蛋白VP0、VP3和VP1，再经酶切后得到重组表达载体，再经小泛素样修饰蛋白酶酶切融合蛋白后在体外组装得到口蹄疫病毒样颗粒。","2010.12.15#公开;2011.03.30#实质审查的生效;2012.10.10#授权","CN201010251915.1","C12N7\u002F04;C12N15\u002F42;C12N15\u002F63;A61K39\u002F135;A61P31\u002F14","孙世琪;郭慧琛;杨顺利;沈小燕;尹双辉;尚佑军;刘湘涛;殷宏;才学鹏",[],[],{"resultType":8,"id":276,"title":277,"abstract":278,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":279,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":280,"ipc":281,"inventors":282,"tags":283,"tagNames":284},"gpi_01203","山羊支原体肺炎二联灭活疫苗及其制备方法","一种山羊支原体肺炎二联灭活疫苗及其制备方法，采用以下方法和步骤制备而成：a制苗用培养基及其制备方法：制苗用培养基为改良KM2培养基；b增殖支原体的程序；c支原体灭活的程序；d疫苗配制程序采用一步乳化法，制成双相油乳剂疫苗；液相成分：占疫苗总量的45～50％，丝状支原体山羊亚种和绵羊肺炎支原体灭活抗原按1∶1混合后，按抗原总量的1％加入1％硫柳汞溶液；油相成分：占疫苗总量的50～55％，ISA206油佐剂；乳化成略带粘滞性的水包油包水型(w\u002Fo\u002Fw)双相油乳剂灭活苗。本发明首次将这两种优势病原联合制备二联疫苗，可同时预防两种病原，避免了用单一病原制备疫苗顾此失彼的缺点，更适合我国生产实际。","2010.06.09#公开;2010.08.11#实质审查的生效;2013.01.30#授权","CN200910117575.0","A61K39\u002F116;A61K39\u002F02;A61P31\u002F04;A61P11\u002F00;C12N1\u002F20","逯忠新;储岳峰;赵萍;高鹏程;贺英",[],[],{"resultType":8,"id":286,"title":287,"abstract":288,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":289,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":290,"ipc":291,"inventors":292,"tags":293,"tagNames":294},"gpi_00405","无病毒非结构蛋白的口蹄疫疫苗及其制备方法","本发明公开了一种制备口蹄疫疫苗的方法。本发明所提供的制备口蹄疫疫苗的方法，包括如下步骤：用口蹄疫病毒非结构蛋白的单克隆抗体去除目标物中的口蹄疫病毒非结构蛋白，再将其制成口蹄疫疫苗；所述目标物为口蹄疫病毒培养物或含有口蹄疫病毒非结构蛋白和口蹄疫病毒结构蛋白的基因工程表达物。用本发明的疫苗免疫动物，再区分感染动物和免疫动物，可信度大大提高，而且制备无病毒非结构蛋白的口蹄疫疫苗的方法简单、方便、有效，不需增加昂贵的设备，适用于规模化应用。因此，本发明的无病毒非结构蛋白的口蹄疫疫苗及其制备方法在检疫口蹄疫中具有重大的意义，在预防和控制口蹄疫中将发挥重要作用。","2008.12.17#公开;2009.02.11#实质审查的生效;2011.10.05#授权","CN200810116725.1","A61K39\u002F135;C07K16\u002F10;C12N5\u002F20;A61P31\u002F14","刘在新;卢曾军;田美娜;李永亮;孙普;曹轶梅;李平花;包慧芳;郭建宏;陈应理;谢宝霞;谢庆阁",[],[],{"resultType":8,"id":296,"title":297,"abstract":298,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":299,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":300,"ipc":95,"inventors":301,"tags":302,"tagNames":303},"gpi_01818","检测鸭疫里默氏杆菌的试剂盒及方法","本发明公开一种用于检测鸭疫里默氏杆菌的试剂盒，以及这种试剂盒的使用方法。本发明涉及的检测鸭疫里默氏杆菌的试剂盒中至少有两对用于进行环介导等温扩增的特异性引物F3、B3、FIP和BIP，为方便使用，本发明的试剂盒中还有甜菜碱、硫酸镁、dNTPs、ThermoPol反应缓冲液和Bst DNA聚合酶；或者还加有显色剂SYBR GREEN I。本发明具有便于在基层应用，检测耗时短，成本低，操作简单方便的优点。","2011.01.19#公开;2011.03.16#实质审查的生效;2012.06.20#授权","CN201010516857.0","郑福英;邱昌庆;蔺国珍;周继章;曹小安;宫晓炜",[],[],{"resultType":8,"id":305,"title":306,"abstract":307,"orgName":40,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":308,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":309,"ipc":310,"inventors":311,"tags":312,"tagNames":313},"gpi_01328","牛口蹄疫病毒Asial型多表位重组疫苗及制备方法","本发明公开了牛口蹄疫病毒Asia1型多表位重组疫苗及其制备方法。该重组疫苗包括以下组分：口蹄疫病毒多表位基因和载体蛋白的融合基因所编码的蛋白以及口蹄疫病毒3D蛋白；其制备方法包括：分别将口蹄疫病毒多表位基因和载体蛋白的融合基因所表达蛋白和口蹄疫病毒3D蛋白稀释后，混和均匀，加入佐剂，乳化，即得。动物模型和动物免疫效力实验表明，本发明牛Asia1表位重组疫苗能产生全面的免疫保护反应，注射免疫牛和豚鼠均能诱导产生高水平的中和抗体，同时也能诱导细胞免疫应答，说明本发明重组疫苗能有效保护动物抵抗口蹄疫病毒强毒攻击。","2010.07.14#公开;2010.09.15#实质审查的生效;2012.09.05#授权","CN201010122010.4","C12N15\u002F42;C12N15\u002F62;C07K14\u002F09;A61K48\u002F00;A61K47\u002F48;A61K39\u002F135;A61P31\u002F14","常惠芸;邵军军;王景锋;丛国正;林彤;独军政;高闪电",[],[],{"resultType":8,"id":315,"title":316,"abstract":317,"orgName":62,"province":13,"date":41,"trl":15,"transferMode":15,"keywords":15,"industry":15,"patentType":16,"legalStatus":318,"isOpenLicense":18,"isRevitalized":19,"techMaturity":15,"starRating":15,"licenseFeeText":15,"patentNo":319,"ipc":320,"inventors":321,"tags":322,"tagNames":323},"gpi_00380","狂犬病毒抗原的制备方法","本发明提供了一种制备狂犬病毒抗原的方法，包括：将狂犬病毒的抗原基因或抗原基因的联合表达组合分别克隆到杆状病毒运载载体中，得到转移表达载体；将转移表达载体与杆状病毒进行共转染以发生同源重组或转座，获得重组杆状病毒；用重组杆状病毒感染昆虫宿主和细胞；培养被感染的昆虫宿主表达相应的狂犬病抗原；收获并纯化所表达的抗原，即得。本发明方法采用杆状病毒表达系统在家蚕生物反应器中生产安全、高效的狂犬病毒抗原，由于所制备的抗原安全性极高，可直接用于生产注射和口服疫苗用以免疫动物。本发明方法可以大幅度降低狂犬病抗原的生产成本，具有安全、高效、能耗少、成本低等诸多优点。","2008.11.19#公开;2009.01.14#实质审查的生效;2012.01.11#授权","CN200810127520.3","C12N15\u002F47;C12N15\u002F866;C07K14\u002F145;A61K39\u002F205;A61K47\u002F12;A61P31\u002F14","柳纪省;张志芳;殷相平;易咏竹;李江涛;李轶女;李志勇;张韵;李宝玉;李学瑞;杨彬;兰喜;白银梅;沈桂芳;舒惠国",[],[],258,1,30,9]