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图1高效低能耗发酵生产细菌纤维素","2026-10-09T19:27:32.696Z",[461,464,465,468,471,472,473],{"code":462,"name":463},"GB-14","食品制造业",{"code":401,"name":402},{"code":466,"name":467},"GB-67","资本市场服务",{"code":469,"name":470},"GB-73","研究和试验发展",{"code":404,"name":405},{"code":425,"name":426},{"code":410,"name":411},[463,402,467,470,405,426,411],{"resultType":386,"id":476,"title":477,"abstract":478,"orgName":390,"province":391,"date":479,"trl":10,"transferMode":10,"keywords":393,"industry":394,"patentType":10,"legalStatus":10,"isOpenLicense":395,"isRevitalized":395,"techMaturity":10,"starRating":10,"licenseFeeText":10,"patentNo":10,"ipc":10,"inventors":10,"tags":480,"tagNames":496},"cmv1bihe90ahmbdd8ihrape44","微生物合成β-榄香烯技术","β-榄香烯（β-elemene, C15H24）是从我国传统中药温郁金中提取的国家二类抗肿瘤药物， 具有低毒、广谱和可破血脑屏障等优异特性，并对213种疾病存在高相关性潜在治疗效果。 目前，临床使用的榄香烯均从植物中提取，由于其提取分离工艺极为复杂，且大多为β-，γ-， δ-榄香烯混合物，导致其价格昂贵，严重限制了榄香烯类抗癌药物的推广和应用。化学合成 方法受原料来源、产品得率、污染排放等因素制约已逐渐被生物合成取代。然而，天然萜烯 合酶因其催化效率低、产物专一性差等问题阻碍了其在工业中应用。针对以上情况，本项目 从合成生物学改造与关键工艺优化两方面入手展开研究，利用人工智能、生物计算和酶生物 催化等技术，获得了催化效率和专一性提高的吉玛烯A（β-榄香烯前体）合酶，并构建了具 有自主知识产权的高产β-榄香烯的大肠杆菌工程菌株。随后，通过发酵控制优化，实现了目 标产物β-榄香烯的高效合成，5L发酵罐产量达到35g\u002FL。 图1微生物发酵合成β-榄香烯","2026-10-09T19:27:32.681Z",[481,482,483,486,489,490,491,492,495],{"code":421,"name":422},{"code":469,"name":470},{"code":484,"name":485},"GB-84","卫生",{"code":487,"name":488},"SEI-01","新一代信息技术产业",{"code":404,"name":405},{"code":446,"name":447},{"code":425,"name":426},{"code":493,"name":494},"CH-33","人工智能",{"code":410,"name":411},[422,470,485,488,405,447,426,494,411],{"resultType":386,"id":498,"title":499,"abstract":500,"orgName":390,"province":391,"date":501,"trl":10,"transferMode":10,"keywords":393,"industry":394,"patentType":10,"legalStatus":10,"isOpenLicense":395,"isRevitalized":395,"techMaturity":10,"starRating":10,"licenseFeeText":10,"patentNo":10,"ipc":10,"inventors":10,"tags":502,"tagNames":511},"cmv1bihde0ah7bdd8529m7aby","生物丁酸连续发酵制备技术","化学法制丁酸是以正丁醛为前体，价格受国际石油价格波动和碳排放等因素影响，目前 在9000-10000元\u002F吨之间。生物法制丁酸是厌氧微生物发酵淀粉糖、秸秆糖等可再生原料获 得，具有绿色低碳属性，但现有工艺受限于原料价格高、产物浓度低，产物分离能耗高等不 利因素。本项目开发了连续发酵耦合在线产物分离成套技术，可以大幅度提高生物丁酸的生 产强度和产量。构建了能够同时利用葡萄糖和乙酸的产丁酸梭菌，显著降低原料成本，为生 物丁酸规模化应用奠定基础。","2026-10-09T19:27:32.649Z",[503,506,507,508],{"code":504,"name":505},"GB-07","石油和天然气开采业",{"code":404,"name":405},{"code":425,"name":426},{"code":509,"name":510},"CH-22","绿色环保",[505,405,426,510],{"resultType":386,"id":513,"title":514,"abstract":515,"orgName":390,"province":391,"date":516,"trl":434,"transferMode":10,"keywords":393,"industry":394,"patentType":10,"legalStatus":10,"isOpenLicense":395,"isRevitalized":395,"techMaturity":10,"starRating":10,"licenseFeeText":10,"patentNo":10,"ipc":10,"inventors":10,"tags":517,"tagNames":520},"cmv1bihcj0agvbdd8v44md1yl","微藻循环式光照兼养培养系统","微藻作为单细胞的光合生物，在培养方式上具有自养、异养、兼养等培养方式。对不同 的微藻种类，商业化生产使用不同的模式。通过目前的验证，绝大多数微藻都可以不同程度 的实现兼养培养，兼养培养具备着光自养和异养的优势，可实现有机碳源和无机碳源有效利 用的培养方法，有助于实现微藻光合固碳和微生物发酵高效生产的双重目标，但是现阶段的 培养普遍由于反应器无法提供足够光源以及无菌操作不易实现等问题，始终无法实现兼养培 养的规模放大。 针对以上问题，开发微藻循环光照兼养培养系统。对不同微藻，模拟并建立循环系统参 数，使微藻在系统中利用有机碳以及循环过程产生的短周期光照，可实现常规持续光照条件 下相同甚至更好的生长效率。在培养工艺上，使用发酵罐连接密闭的管路系统，外接管路系 统的体积较小易于灭菌。放大至百升或者吨级后，在无菌操作、照明设备和管路成本上的投 入上可控，较好的克服污染和成本的问题。该系统可帮助今后实现兼养培养的规模化放大。 图1.微藻循环式光照兼养系统的培养装置基本示意图  项目阶段与进展 -77- 通过对三种微藻（微拟球藻、三角褐指藻、麦卡藻）在系统培养过程中的生化分析和组 学分析，建立不同微藻的匹配性培养方案，涉及循环流速，循环系统体积比，光照强度调节， 有机碳源补充方式等，实现在5 L级培养装置中，单批次培养周期（10天）的生物量积累相 较于自养条件下提高10~15倍，并细化了规模放大的方案。  知识产权情况 已申请相关专利3项，授权2项。  应用前景 在微藻种质资源的开发过程中，人们不断发现微藻的经济价值，微藻含有着丰富的油脂、 蛋白质、多糖和色素等代谢产物。在生产过程中","2026-10-09T19:27:32.616Z",[518,519],{"code":404,"name":405},{"code":425,"name":426},[405,426],{"resultType":386,"id":522,"title":523,"abstract":524,"orgName":390,"province":391,"date":525,"trl":434,"transferMode":10,"keywords":393,"industry":394,"patentType":10,"legalStatus":10,"isOpenLicense":395,"isRevitalized":395,"techMaturity":10,"starRating":10,"licenseFeeText":10,"patentNo":10,"ipc":10,"inventors":10,"tags":526,"tagNames":541},"cmv1bih1h0aaxbdd8f8c7rz3f","木质纤维素整合生物糖化技术","秸秆等木质纤维素储量巨大，将其进行降解糖化可以为大规模生物制造提供廉价的非粮 碳源。目前常规木质纤维素糖化方法是添加游离纤维素酶及半纤维素酶，但纤维素酶生产成 本较高，且核心技术掌握在少数国外公司手中，严重限制了木质纤维素的工业化利用。整合 生物糖化(CBS)是利用全细胞催化剂自身产酶，在一个反应器中完成从纤维素降解到可发酵 糖的全过程，不依赖于商业化纤维素酶制剂，从而降低成本、简化过程，可发酵糖液可灵活 对接下游有机酸、功能油脂、饲料蛋白等发酵工艺。","2026-10-09T19:27:32.197Z",[527,530,533,536,537,538],{"code":528,"name":529},"GB-13","农副食品加工业",{"code":531,"name":532},"GB-28","化学纤维制造业",{"code":534,"name":535},"SEI-04","生物产业",{"code":404,"name":405},{"code":425,"name":426},{"code":539,"name":540},"CH-30","制造",[529,532,535,405,426,540],{"resultType":386,"id":543,"title":544,"abstract":545,"orgName":390,"province":391,"date":546,"trl":10,"transferMode":10,"keywords":393,"industry":394,"patentType":10,"legalStatus":10,"isOpenLicense":395,"isRevitalized":395,"techMaturity":10,"starRating":10,"licenseFeeText":10,"patentNo":10,"ipc":10,"inventors":10,"tags":547,"tagNames":572},"cmv1bih100aaibdd8mcu9fmox","生物过程优化放大及智能生物反应器技术","一、生物过程优化放大技术 以各种发酵产品为对象开展微生物细胞大规模培养过程研究，实现过程优化与放大，由 此形成先进的生产工艺和工程放大技术。针对微生物发酵生物过程的高度复杂性，本研究团 队在长期的研究和实践中，形成了微生物过程多尺度参数相关分析过程优化方法和反应器流 场特性与生理特性相结合的发酵过程放大方法，从工业过程中凝练出科学问题，开展基础研 究、关键共性技术研究与产品技术研究，形成了具有自主知识产权的专用研究设备，以工艺 工程装备一体化为工厂企业服务，形成的研究技术在医药、食品、轻工、农业、能源、环境 等领域发酵产品中广泛应用，为相关的工业生物技术企业技术进步、提升产业技术水平做出 重大贡献。 形成的关键核心技术包括：1）多尺度参数相关过程优化研究技术；2）CFD流场特性与 生理特性研究相结合过程放大技术；3）过程宏观代谢流、传感器配置与在线数据处理技术； 4）发酵过程计算机数据处理与控制软件包；5）稳定性13C微观代谢流测定技术；6）生物 过程大数据与智能分析平台；7）大型发酵罐工程设计与改造技术；8）联动并行多尺度反应 器系列开发技术；9)生物过程在线分析技术（PAT）。","2026-10-09T19:27:32.180Z",[548,551,552,553,556,559,562,563,564,565,566,567,570],{"code":549,"name":550},"GB-01","农业",{"code":462,"name":463},{"code":421,"name":422},{"code":554,"name":555},"GB-39","计算机、通信和其他电子设备制造业",{"code":557,"name":558},"GB-40","仪器仪表制造业",{"code":560,"name":561},"GB-65","软件和信息技术服务业",{"code":469,"name":470},{"code":487,"name":488},{"code":404,"name":405},{"code":446,"name":447},{"code":425,"name":426},{"code":568,"name":569},"CH-24","现代农业",{"code":571,"name":117},"CH-35",[550,463,422,555,558,561,470,488,405,447,426,569,117],{"resultType":386,"id":574,"title":575,"abstract":576,"orgName":390,"province":391,"date":577,"trl":10,"transferMode":10,"keywords":393,"industry":394,"patentType":10,"legalStatus":10,"isOpenLicense":395,"isRevitalized":395,"techMaturity":10,"starRating":10,"licenseFeeText":10,"patentNo":10,"ipc":10,"inventors":10,"tags":578,"tagNames":595},"cmv1bigzm0a9tbdd8h1kxm7tt","微藻合成生物技术与绿色生物制造","随着经济持续增长、核心人群扩容，中国化妆品行业逐步发展为一个初具规模、极富生 机活力的产业，迎来了行业的黄金时代。成分新星-甘油葡糖苷（以下简称GG）的发现与应 用，除了能达到与透明质酸等同的保湿效果以外，GG优异的透皮性，有效活性成分可直达 皮肤真皮层，发挥抗衰去皱、抗炎舒敏、护发养发、提质亮肤等多种生理功效，广泛应用于 护肤养发等产品中，逐渐为品牌方和消费者所接受和追捧。 针对市场上GG多构型、多杂质、非天然、不环保、高成本的问题，青岛中科蓝智生物 科技发展有限公司（以下简称中科蓝智）依托中国科学院青岛生物能源与过程研究所（以下 简称研究所）的强大科研实力，成功开发国际首创微藻合成高值天然产物甘油葡糖苷先进生 物制造技术—SCGP技术（Smart Cyano Glucosylglycerol Polygeneration Technology），实现 高品质天然GG产品的量产和销售。 公司立足传统制造业绿色发展的重大科技创新需求，服务于国家“碳达峰、碳中和”的发 展战略，面向大健康产业，应用系统生物技术、合成生物技术、过程工程技术，打造高品质 天然藻类活性物质的研发生产体系，实现化妆品、食品、保健品和医药产品及原料的绿色生 物制造。 图1螺旋藻中GG的生物合成途径及生产流程图 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基于解耦热转化原理，本技术通过双流化床反应器，实现气化与燃烧在两个 不同反应器进行。通过燃烧产生的热灰作为供热介质提供气化反应所需热量，从 而避免了传统单床空气气化煤气热值低、碳转化率低问题。该技术可根据不同气 化原料，调整反应条件（温度、压力、气氛、循环倍率等），以在较温和的反应 条件下实现较高的煤气热值。本技术运行稳定，操作灵活，并可以结合用户要求 优化反应装置的运行。使用松木屑、秸秆等原料进行气化时，热值最高可达 14MJ\u002Fm3，产气率～1.5m3\u002Fkg。 专利及进展情况 申请生物质热解、气化相关发明专利8 项，其中获授权 6项。实用新型专利 1 项，授权1 项。 产业化前景分析 生物质能源是重要的可再生能源。我国生物质能资源极为丰富，仅秸秆年产 量约为 7亿吨，相当于 4亿吨标煤。生物质气化技术是利用生物质能的一种重要 方式。发展中小型生物质气化炉是解决农村能源利用洁净化的重要方向。传统流 化床空气气化技术热值低、焦油含量高、碳转化率低。生物质双床气化将气化和 燃烧分开，与单流化床气化相比，双床工艺能够达到更高的碳转化率，并产生热 值更高的煤气；同时反应条件相对温和，易于实现，适应性强，具有良好的推广 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挥发性有机物（VOCs）是重要的大气环境污染物之一，也是形成细颗粒物 (PM2.5)和臭氧的重要前体物质。VOCs 治理目前是我国大气污染治理的重点和难 点。“十三五”期间 VOCs 治理市场将迎来爆发式增长，市场规模预计将超 2000 亿元。在集装箱制造、印刷、家具喷涂、电子制造、化工制药等行业生产过程中 会有大量的 VOCs排放，采用流化床先吸附浓缩再催化燃烧或溶剂回收技术，具 有环境友好、节能减排和显著的社会经济效益，推广应用前景良好。 转化方式 技术转让 许可使用 2万m3\u002Fh的流化床吸附浓缩-催化燃烧装置适用于流化床的高耐磨性能球形吸附剂 双流化床气化技术","2026-10-09T19:27:31.646Z","技术转让 许可使用 2万m3\u002Fh的流化床吸附浓缩-催化燃烧装置适用于流化床的高耐磨性能球形吸附剂 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本项目以流化床为反应器，拜耳法氢氧化铝为原料，基于热力学计算，以及 反应过程的机理分析，设计开发了低温分解-低温氯化制备高纯无水氯化铝的短 流程技术。采用氢氧化铝的低温分解技术，获得高比表面和高活性的氧化铝，通 过引入气质碳源强化了反应介质间的传递和反应过程，突破了反应过程动力学， 高活性的氧化铝在低温可被快速氯化。通过工艺条件的优化，获得高纯无水氯化 铝的工艺参数条件，高纯无水氯化铝的纯度可达到 4N 以上。本技术具有反应条 件温和，生产效率高，清洁环保等特点。 专利及进展情况 申请了 2项国内专利。目前，已完成实验室小试实验工作，获取了关键技术 参数。 产业化前景分析 无水氯化铝作为重要的化工产品，目前主要应用于有机化工合成领域，国内 需求量超过 30万吨\u002F年，同时作为最具发展潜质的大规模储能电池—铝离子电池 电解液的主要活性组分，随着可再生能源技术和储能产业的发展，高纯无水氯化 铝将具有更为广阔的市场空间。相对于现有的铝锭法，新技术以廉价的氢氧化铝 为原料，短流程高效清洁地生产高纯无水氯化铝产品，生产成本下降 35%以上， 且可实现单套 10万吨级规模化生产，将具有良好的市场竞争优势和发展应用前 景。 转化方式 技术转让 许可使用 挥发性有机物（VOCs）流化床吸附浓缩技术","2026-10-09T19:27:31.639Z","技术转让 许可使用 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有机硅材料的基本原料是有机硅单体，有机硅单体生产过程中的二甲基二氯 硅烷（M2）是有机硅材料的主要原料，占有机硅单体总量的 85-90%，而铜基催 化剂对 M2 的选择性是有机硅行业的关键技术指标。基于此，经过近十年努力， 本项目开发了有机硅单体合成工业使用的多种高效铜基复合催化剂产品，在催化 理论认识、结构调控技术和生产工艺上都有较大创新。在理论上，从分子催化的 角度认识了铜基复合催化材料中各组分的功能作用，以及反应的催化机理和催化 剂中多元组分的协调机制。在催化剂结构调控技术上，从纳米结构单元入手，认 识到铜基纳微复合催化材料不同界面和功能的形成、演化和作用机制等问题，采 用催化剂纳米晶粒、纳米合金和纳米缺陷作为活性位的调控技术手段，实现铜基 复合催化材料的设计-制备-性能的有效调控和性能优化，提高催化活性，延长活 性周期。在生产工艺技术上，开发了绿色无污染工艺，生产过程无废水、废气、 废渣排放，设备投资少，占地小，原料适用性强，可选择不同的铜粉、氧化铜粉、 氧化亚铜粉等为原料，生产成本低，易于规模化放大生产。在相关企业建立了催 化剂放大生产线，生产上百吨催化剂并进行了初步的工业测试，产品性能优于进 口和国产催化剂。 专利及进展情况 相关研究成果具有自主知识产权，已申请和授权发明专利 20 余件，发表相 关科学研究文章 10多篇，相关技术荣获 2011中国产学研合作创新成果奖，实现 了实验室放大制备并完成了工业生产示范，形成了具有自主知识产权的规模化制 备工艺技术。具体可参见本研发团队网页：http:\u002F\u002Fcpme.mpcs.cn\u002F 产业化前景分析 2017","2026-10-09T19:27:31.633Z","技术转让 许可使用 合作开发 面谈 高纯无水氯化铝制备新技术",[761,762,763,764,765,766,767,768,769],{"code":398,"name":399},{"code":469,"name":470},{"code":650,"name":651},{"code":534,"name":535},{"code":621,"name":622},{"code":404,"name":405},{"code":655,"name":656},{"code":626,"name":627},{"code":539,"name":540},[399,470,651,535,622,405,656,627,540],{"resultType":386,"id":772,"title":773,"abstract":774,"orgName":600,"province":10,"date":775,"trl":13,"transferMode":776,"keywords":393,"industry":678,"patentType":10,"legalStatus":10,"isOpenLicense":395,"isRevitalized":395,"techMaturity":10,"starRating":10,"licenseFeeText":10,"patentNo":10,"ipc":10,"inventors":10,"tags":777,"tagNames":809},"cmv1bignt09tcbdd8hjueghxu","阻燃型玻纤增强热塑性复合材料的可控制备技术","技术简介及特点 玻纤复合材料以其质量轻强度高的性能特征正成为新一代的结构材料，广泛 应用于航空航天、轨道交通、机械制造、建筑等多个领域。然而，作为纤维复合 材料中最常用的聚丙烯树脂，如何克服就是耐高温性差的不足，使玻纤复合材料 具有阻燃性，从而提高安全性和减少火灾损失，是玻纤复合材料拓宽应用市场亟 需解决的关键性问题。但卤素阻燃剂燃烧时烟雾大、放出有毒和腐蚀性气体等， 造成二次污染。研究新的高效无卤阻燃剂成为阻燃研究的重要方向，但IFR 添加 量相对较大，会影响阻燃LGFPP 的力学性能，因此，同时兼顾力学性能与阻燃性 能成为一个制约其推广应用的重大难题。本项目采用 IFR阻燃 LGFPP复合材料， 研究了不同的 IFR及其添加量对 LGFPP复合材料阻燃性能、燃烧性能和力学性能 的影响。阻燃测试结果表明，阻燃剂垂直燃烧等级达到 UL94V0级，但流动性略 有降低。目前可批量生产力学和阻燃性能均达标的玻纤复合材料，用于汽车内饰 件、电池箱体等。 项目进展情况 目前阻燃造粒产能 150公斤\u002F小时，阻燃玻纤增强 pp产能 18公斤\u002F小时，可 批量生产力学性能和阻燃性能均能达到参考标准的长玻纤复合材料，产能达 2200 吨\u002F年，用于汽车内饰件、电池箱体等。 产业化前景分析 随着风电、轨道交通、城市基建、环保等领域的市场需求增加，带动复合材 料制品市场持续升温。2015 年，纤维增强热塑性产品产量为 176.4 万吨，同比 增长 9.23%。因此，对其阻燃性能的研究具有重大的市场潜力。本项目以非卤的 膨胀系阻燃剂（IFR）为研究对象，通过对不同阻燃剂阻燃性能筛选及配方优化， 生产的复材","2026-10-09T19:27:31.625Z","合作开发 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烟气中 SO 排放（酸雨，PM2.5）对生态环境和人体健康带来严重影响，同 时造成硫资源的严重浪费，据统计，排放1 吨SO 造成直接经济损失 2万元。目 前运行的烟气脱硫技术主要是湿法脱硫，但该方法腐蚀严重，副产物难处理，SO 不能回收利用。本团队开发了离子液体法烟气脱硫及硫资源化利用新技术，该技 术具有以下特点：1.能耗低，工艺简单，该离子液体价格便宜，且可以循环利用； 2.捕集率> 99%，符合目前 SO 排放标准；3.可回收高度的 SO ，纯度> 98%，进 2 2 一步制备硫酸等，实现硫的资源化利用，降低脱硫成本。 专利及进展情况 已申请 5项发明专利，其中授权 3项。与国电合作在贵州福泉电厂建立了处 理量 300Nm3\u002F小时及 10000Nm3\u002F小时的烟气脱硫装置，脱硫率>99%。2017 年通过 了中国环境科学学会的科技成果鉴定，关键技术指标达到“国际领先水平”。 产业化前景分析 该技术脱除烟气中 SO ，可回收宝贵的硫资源，可作为生产硫酸、液体二氧 化硫等优良原料。该技术实现了烟气脱硫装置的高效化、资源化，符合国家循环 经济的发展目标，对保护社会环境和人类的健康有重要意义。因此本技术特别适 合于以高硫煤为原料的焦炉烟气、烧结烟气以及电厂烟气，该技术是彻底解决高 硫地区烟气治理的必由之路，同时也将促进我国煤炭、电力、化工工业的良性发 展，产生积极的经济效益和社会效益，因此该技术在我国具有很好的推广应用价 值。 转化方式 技术转让 许可使用 阻燃型玻纤增强热塑性复合材料的可控制备技术","2026-10-09T19:27:31.618Z","技术转让 许可使用 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化妆品和个人护理用品、消毒洗剂、工业助剂、工业清洗、农药乳剂等领域。醇 醚（烷基）糖苷是“十一五”国家科技支撑计划的最新科技成果之一，也是“十 二五”国家产业化推广项目之一。目前，醇醚（烷基）糖苷的分离纯化是通过降 膜式薄膜蒸发器在高温（180 ℃）、高真空（2mmHg）下除去未反应的脂肪醇聚氧 乙烯醚\u002F脂肪醇。该分离工艺存在能耗特高、产品易焦化（影响产品价格）、后处 理程序复杂（HO 脱色）、产品为10%－50%的水溶液，无法得到固含量高的产品。 2 2 本项目自主开发了固含量高（固含量>98%）的醇醚（烷基）糖苷新技术。该技术 具有以下特点：1.新工艺常温常压操作，条件温和；2.新工艺能耗低（与传统工 艺相比，能耗降低－50%）；3.产品不需要脱色，固含量>98%；4.产品是固体，易 于运输，运输成本低。 专利及进展情况 已申请 5项发明专利，其中授权 1项。在安阳建立了3000 吨\u002F年固态醇醚糖 苷清洁工业生产装置，实现了稳定运行，在国内外首次获得纯度大于 98%粉末状 醇醚糖苷固体新产品。2016 年通过了中国石油和化学工业联合会组织的科技成 果鉴定会，鉴定委员会一致认为，高纯度粉末状醇醚糖苷新产品和新工艺属国内 外首创，关键技术指标达到国际领先水平。 产业化前景分析 2016年全球表面活性剂产销量2060万吨，市场销售额达到354亿美元，年均 增长率约5.8%。预计2019年，全球表面活性剂市场总量将","2026-10-09T19:27:31.611Z","技术转让 许可使用 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骤包括层析、超滤和冷冻干燥等。采用SDS-PAGE 电泳、MALDI-TOF-MS 质谱、高 效凝胶过滤色谱以及酶联免疫吸附法(ELISA)对转铁蛋白分析检测，纯度大于 99%，收率为 79%。我们将转铁蛋白纯化工艺进行放大，制备人转铁蛋白10 克， 纯度大于 99%（高于 sigma标准品纯度），转铁蛋白收率大于80%。该工艺具有操 作简单、重复性好和易于放大等特点，制备的转铁蛋白纯度高、安全性好，可作 为无血清培养基的关键组分，为无血清培养基的研制与开发提供保障。 产业化前景分析 转铁蛋白是无血清培养基的关键组分之一，对促进哺乳动物细胞的生长具有 重要意义。一般情况下无血清培养基中转铁蛋白必须至少有5μg\u002FmL，胰岛素才 能起作用。随着哺乳动物细胞培养种类、规模和应用范围的不断扩大以及安全性 能要求的不断提高，无血清培养基的需求与日俱增，作为其关键组分的转铁蛋白 的需求量也逐年增加，市场前景十分广阔。此外，转铁蛋白在生物医药领域也有 重要应用，Tf 可以结合许多治疗或诊断相关的金属离子，并且这种结合物可以 被癌症细胞表面过度表达的 Tf受体（TfR）识别，由 Tf和 TfR介导的药物传递 系统在近年来受到了广泛关注，包括 Tf 作为载体传递金属药物、化疗药物、高","2026-10-09T19:27:31.605Z","技术转让 许可使用 醇醚（烷基）糖苷类绿色表面活性剂 分离纯化新技术",[865,866,867,868,869,870,871,872,873,874,875,876,877],{"code":398,"name":399},{"code":421,"name":422},{"code":583,"name":584},{"code":650,"name":651},{"code":534,"name":535},{"code":621,"name":622},{"code":404,"name":405},{"code":446,"name":447},{"code":655,"name":656},{"code":626,"name":627},{"code":539,"name":540},{"code":407,"name":408},{"code":722,"name":723},[399,422,584,651,535,622,405,447,656,627,540,408,723],{"resultType":386,"id":880,"title":881,"abstract":882,"orgName":600,"province":10,"date":883,"trl":13,"transferMode":884,"keywords":393,"industry":678,"patentType":10,"legalStatus":10,"isOpenLicense":395,"isRevitalized":395,"techMaturity":10,"starRating":10,"licenseFeeText":10,"patentNo":10,"ipc":10,"inventors":10,"tags":885,"tagNames":902},"cmv1bign709rlbdd8ikfmbrxb","新一代智能化蛋白层析系统","项目简介及特点 新一代智能化蛋白层析系统是基于国家 863重点、中科院重大仪器研制项目 的开发成果，针对我国生物技术产品研制和产业化过程中，最关键的分离纯化装 备长期依赖进口的现状，开展了创新性研制和研究工作。研制和开发了适合生物 分子分离纯化的层析装备和技术，实现了装备和工艺的标准化、工程化、产业化。 智能化蛋白层析系统通用性强、自动化高、操作简便快捷，各项性能指标达到了 进口设备的标准，在系统控制平台、软件数据库等方面的参数已经超过了进口设 备。目前已经制定了企业标准，通过了 ISO9001认证，实现了规模化生产。 专利及进展情况 相关研究成果具有自主知识产权，授权了多项发明专利（ZL201010127899.5; ZL201310062077.7; ZL201310088098.6; ZL201310062061.6;ZL201310198644.1; ZL201310701298.4; ZL201310701299.9; ZL2016100417220）。并荣获中国分析 测试协会科学技术奖“CAIA 奖”2013 一等奖1 项和中国仪器仪表学会2011 科技 创新奖 1项。 产业化前景分析 前我国蛋白层析系统年需求量为 2000余台，市场超过了 10亿元人民币，并 且随着生物产业的发展和技术的更新换代，需求量将逐年升高。本项目的产品已 在包括华兰生物、双鹭药业等 50 余家企事业单位得到了应用。突破了国外进口 同类产品的垄断，获得了良好的评价。并且开发了多柱组合层析和膜过滤集成装 备等一系列先进技术，可以满足生物技术产品生产和分析的不同需求，具有良好 的推广应用前景。","2026-10-09T19:27:31.598Z","合作开发 风险投资 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子法生产多晶硅技术，做为国家重点研发项目虽然已有中国恩菲等研发机构开发 了工艺且实现的量产，由于国外技术封锁，提纯技术是工艺核心单元也是影响其 产品质量的技术瓶颈，产品纯度高(9个 9)和提纯工艺能耗高是两个重要技术指 标。项目团队自 2008 以来一直从事改良西门子法生产多晶硅工艺氯硅烷体系提 纯单元关键技术的研发，针对提纯产品三氯氢硅纯度高（9 个9）和能耗高（回 流比大于 50）的技术瓶颈，一是创新性地开发了高效IPE-PAC 双层丝网填料(理 论板数大于 8)替代板式塔分离效率不高的缺点，打破了国外德国WacKer 公司和 美国 REC公司的技术垄断，彻底解决多晶硅生产技术的提纯纯度不达标直接影响 产品质量的技术瓶颈；二是开发了系统闭式多级提纯和多效热耦合集成关键技术， 提出后产品稳定在 9个 9 以上，系统能耗节能＞40%（能耗＜24 吨蒸汽\u002F吨产品）， 物料利用率＞99%，技术指标均处于国际领先水平。 专利及进展情况 已申请 8 项发明专利，其中授权5 项，形成了一整套工艺技术+核心装置的 专利集群。自 2009年建立了 1000吨\u002F年多晶硅氯硅烷提纯装置以来，陆续在国 内建立 20余套工业示范装置（最大单套规模3 万吨\u002F年多晶硅装置），对国内 20 余家近 90%以上多晶硅企业进行了技术转让，示范装置均实现了稳定运行，在氯 硅烷提纯与节能领域逐渐形成了具有自主知识产权的民族技术品牌，近年来多次 与国外专利商的技","2026-10-09T19:27:31.592Z","技术转让 许可使用 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）；2011年，“芦笋多糖提取分离及生物活性研究”， 国际先进水平。（河北省登记号：20110163 ）；2010年，“芦笋皂苷提取分离 工艺研究”，国际先进水平。（河北省登记号：20100781）。相关发明专利：ZL 201010606933.7；ZL 201010186922.8；ZL 201110393381；ZL 201010140646.1； ZL 201110329486.X。 产业化前景分析 芦笋享有“蔬菜之王”的美誉。富有天冬酰胺等18种氨基酸、硒、锌、锰等 15种微量元素，以及多种维生素，具有很高的营养价值；其次，芦笋含芦笋多糖、 皂苷、黄酮等生物活性物质，能够调节人体代谢，长期食用可以增强免疫力，对 高血压、糖尿病、前列腺炎、乳腺癌等具有很好的预防和治疗效果。随着大家对 芦笋认识的逐步深入，芦笋的各项功能得到有效开发利用，芦笋的种植加工业蓬 勃发展，芦笋日益受到消费者和广大笋农的青睐，","2026-10-09T19:27:31.585Z","技术转让 许可使用 面谈 高效电子级多晶硅氯硅烷提纯 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肿瘤活性，可改善血浆中的氧扩散及消耗，也可用于治疗高血压、冠心病、高血 脂等症。针对藏红花药材、大规模培养的藏红花细胞、含藏红花素的植物等三种 原料，开发了高效提取纯化藏红花素和藏红花酸的技术。以栀子果为原料，采用 循环超声提取技术，常温快速提取藏红花素，提取率达到98%以上，栀子黄色素 粗提物色价达到56；经大孔树脂纯化，可得到OD值比率约0.3-0.4、色价为500 的色素精制品；栀子黄色素经高效催化裂解、分离、纯化可得到纯度在97%以上 的藏红花酸；建立了藏红花酸包合技术，有效改善藏红花酸的水溶性，溶解度提 高至260μg\u002Fml以上。 专利及进展情况 申请专利5项（已获授权3项）。已完成小试和部分中试，可以进行中试和产 业化开发。 产业化前景分析 藏红花酸具有多不饱和共轭烯酸结构，具有保护肝脏、抑制肿瘤、抗氧化、 提高缺氧耐受力、改善视力等多种药理功能，属于医疗价值极高的药品、功能性 食品及化妆品原料。随着藏红花酸及相关产品的开发，其市场需求量不断增加， 由于资源和技术的限制，远远无法满足市场需求。藏红花中含有10%左右的藏红 花酸，但藏红花原料（主产地伊朗）价格昂贵，而栀子果中含有0.5%左右的藏红 花苷（可转化为藏红花酸），并且栀子果价格低廉，原料易得，在我国的种植规 模大、分布广，以浙江、江西、湖南、福建、河南为主要产地；因此，栀子果","2026-10-09T19:27:31.579Z","技术转让 许可使用 面谈 利用芦笋下脚料生产皂苷、多糖等功能产品",[952,953,954,955,956,957,958,959,960,961],{"code":549,"name":550},{"code":462,"name":463},{"code":484,"name":485},{"code":650,"name":651},{"code":534,"name":535},{"code":621,"name":622},{"code":404,"name":405},{"code":655,"name":656},{"code":626,"name":627},{"code":539,"name":540},[550,463,485,651,535,622,405,656,627,540],{"resultType":386,"id":964,"title":965,"abstract":966,"orgName":600,"province":10,"date":967,"trl":32,"transferMode":968,"keywords":393,"industry":678,"patentType":10,"legalStatus":10,"isOpenLicense":395,"isRevitalized":395,"techMaturity":10,"starRating":10,"licenseFeeText":10,"patentNo":10,"ipc":10,"inventors":10,"tags":969,"tagNames":981},"cmv1bigmm09q6bdd80fm06nt8","ε-聚赖氨酸产业化生产及应用","技术简介及特点 ε-聚赖氨酸（ε-poly-L-lysine,ε-PL）作为一种天然的微生物代谢产品， 具有广谱抗菌性，对革兰氏阳性菌、革兰氏阴性菌、酵母菌、霉菌、噬菌体等均 有良好的抑制作用，是目前天然防腐产品中具有优良防腐性能和巨大商业潜力的 微生物类食品防腐剂，相比于苯甲酸类、山梨酸类等传统化学食品防腐剂和其它 生物食品防腐剂（如Nisin等），ε-聚赖氨酸具有抑菌谱广、抑菌能力强、耐高 温（120℃）、水溶性好、不影响食品风味、使用量低和安全性高等优点，在食品 中添加量仅为0.01-0.5%，具有较好的经济性。 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