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的针对不同研究目的，从代谢物的靶标分析、非靶标分析和拟靶标分析3个层次 的一整套基于色谱-质谱联用技术的代谢组学平台，并将其应用于病变标记物的 发现和疾病分型，疗效评价和作用机理研究以及植物和微生物的代谢组学研究中， 取得了丰硕的成果。“基于色谱-质谱联用技术的代谢组学分析平台及应用”， 2012年获辽宁省科技发明奖二等奖。“基于液相色谱-质谱联用的高覆盖代谢组 学方法开发及应用”，2020 年获中国分析测试协会科学技术奖 CAIA 奖。在科研 实践中，已实现了代谢组学在样品采集、运输、存储、分析、数据处理各个环节 的标准化操作，授权发明专利和软件著作权 10 余项，涉及样本采集、分析方法、 数据处理、标志物发现等，为本项目提供了良好的技术平台。 该技术已用于疾病生物标记物的发现，营养代谢组学，植物、微生物代谢组 学的研究。大连化学物理研究所是国内最早开展代谢组学技术服务的单位，构建 的多层次代谢组学平台具有国际先进水平，并享有良好的国内外知名度。我们已 经成功解决了困扰质谱代谢组学研究的几个瓶颈，实现了高通量大规模样品分析 到海量数据分析的整个研究过程的SOP，基本可以“定制式”地把整个平台应用 于农业、植物、临床医学、药物","2026-10-09T19:27:27.949Z","：以技 术入股方式合作成立代谢组学研究院，合作方提供仪器、场地等硬件投入和市场 推广，大连化物所提供全套代谢组学技术，及后期的技术的整合和优化及新方法 开发。此外，大连化物所代谢组学技术经过长期的科研应用，已实现组学技术的 辽宁省大连市中山路457号 116023 Tel: 0411-84379025 http:\u002F\u002Fwww.dicp.ac.cn 标准化，同时对糖尿病、糖尿病眼病、卵巢癌、肝癌、前列腺癌等疾病的代谢特 征和潜在标志物研究取得了良好的成果，目前已经申请了 10 余项标志物试剂盒 专利。项目实施风险较低。  投资与收益 可参照深圳“华大基因”的方法，建立《代谢组学研究院》。合作方投资金 额不少于1000万元，用于购置实验设备、场地和人员等支出。 合资公司将以大连化学物理研究所的代谢组学平台为核心，构建面向全国的 大型代谢组学科研服务中心，为科研及产业界提供国家先进水平的代谢组学技术 服务，在此基础上致力于将现有的代谢组学研究积累转化为能够在临床大规模应 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(Metabolomics ormetabonomics) 是 20 世纪 90 年代中期发展起来的一门新兴 有极大的发展潜力。因此项目将具有可观的投资回报率。 学科，是系统生物学的重要组成部分。代谢组学通过检测内源性代谢产物在扰动下的变化，对生物 系统进行整体及其动态变化规律的研究，已被广泛应用于疾病诊断、医药研制开发、营养食品科 合作方式 学、毒理学、环境学，植物学等与人类健康密切相关的领域。 技术入股 中国科学院大连化学物理研究所是国内最早开展代谢组学研究的科研机构，承担并已完成了 国家“863”第一个关于代谢组学技术平台的研究项目，以及国家杰出青年基金、 重点基金、国家 投资规模 科技重大专项等。已构建了具有国际先进水平的针对不同研究目的，从代谢物的靶标分析、非靶标 分析和拟靶标分析3个层次的一整套基于色谱- 质谱联用技术的代谢组学平台，并将其应用于病 1000 万 ~5000 万 变标记物的发现和疾病分型，疗效评价和作用机理研究以及植物和微生物的代谢组学研究中，取 得了丰硕的成果。“基于色谱-质谱联用技术的代谢组学分析平台及应用”，2012年获辽宁省科技 发明奖二等奖。“基于液相色谱-质谱联用的高覆盖代谢组学方法开发及应用”，2020年获中国分 析测试协会科学技术奖CAIA奖。在科研实践中，已实现了代谢组学在样品采集、运输、存储、分析、 数据处理各个环节的标准化操作，授权发明专利和软件著作权10余项，涉及样本采集、分析方法、 数据处理、标志物发现等，为本项目提供了良好的技术平台。 该技术已用于疾病生物标记物的发现，营养代谢组学，植物、微生物代谢组学的研究。大连化 学物理研究所是国内","2026-10-09T19:27:27.847Z","学、毒理学、环境学，植物学等与人类健康密切相关的领域。 技术入股 中国科学院大连化学物理研究所是国内最早开展代谢组学研究的科研机构，承担并已完成了 国家“863”第一个关于代谢组学技术平台的研究项目，以及国家杰出青年基金、 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