[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"tags-groups":3,"chains-groupcat":4,"experts-list":5,"experts-coverage":50},[],[],{"list":6,"total":48,"page":48,"pageSize":49,"totalPages":48},[7],{"id":8,"name":9,"orgName":10,"school":11,"gender":12,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":15,"intro":16,"province":17,"completeness":18,"avatarAuthorized":19,"sourceUrl":20,"nameValid":21,"tags":22,"tagNames":47},"e5cb857f-19f2-4f6f-983e-279c78293537","吴静","西安交通大学生命科学与技术学院","西安交通大学","女","副教授",null,"近年来研究方向为生物化学和细胞生物学基础研究，主要从事肿瘤和衰老等疾病的发病机制、代谢调控和信号传导等基础研究，近；年所取得的研究成果已在 Cell 以及 Cell Metabolism 等国际一流杂志发表；余篇。主持国家自然科学基金面上项目、国家自然科学基金青年项目、教育部博士学科点新教工基金等资助项目，项目经费累计约 100 万元；Wu J , Liu J, Lapenta K, Desrouleaux R, Li MD, Yang X. Regulation of the urea cycle by CPS1 O-GlcNAcylation in response to dietary restriction and aging. J Mol Cell Biol. 2022；Lu X, Yang P, Zhao X, Jiang M, Hu S, Ouyang Y, Zeng L, Wu J . OGDH mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer. Exp Cell Res. 2019；Lu X, Wu N, Yang W, Sun J, Yan K, Wu J . OGDH promotes the progression of gastric cancer by regulating mitochondrial bioenergetics and Wnt\u002Fβ-catenin signal pathway. OncoTargets and Therapy. 2019；Singh J.P., K. Zhang, J. Wu , X. Yang. O-GlcNAc signaling in cancer metabolism and epigenetics. Cancer Lett. 2015；Wu J , Damon B, Sadlonova A, Whisenhunt TR, Rustgi AK, Nie YZ, Paterson AJ, Yang X. O-GlcNAc Transferase Is Critical for TLE-Mediated Repression of Canonical Wnt Signaling. J Biol Chem. 2014；Zheng A, Li H, Wang X, Feng Z, Xu J, Cao K, Zhou B, Wu J* , Liu J. Anticancer Effect of a Curcumin Derivative B63；Zhang H, Wu J , Dong H, Khan SA, Chu ML, Tsuda T. Fibulin-2 Deficiency Attenuates Angiotensin II-Induced Cardiac Hypertrophy By Reducing Transforming Growth Factor- β Signaling. Clin Sci (Lond). 2014 (Co-first author；Ruan H.B., M.O. Dietrich, Z.W. Liu, M.D. Li, J.P. Singh, K. Qian, K. Zhang, M.R. Zimmer, J. Wu , T.L. Horvath, X. Yang. O-GlcNAc transferase-controlled AgRP neurons suppress browning of white fat. Cell. 2014；Ruan H.B., J.P. Singh, M.D. Li, J. Wu , X. Yang. Cracking the O-GlcNAc code in metabolism. Trends Endocrinol. Metab. 2013；Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J , Yates JR 3rd, Yang X. O-GlcNAc transferase\u002Fhost cell factor C1 complex regulates gluconeogenesis by modulating PGC-1 α stability. Cell Metab. 2012；Li MD, Ruan HB, Singh JP, Zhao L, Zhao T, Azarhoush S, Wu J , Evans RM, Yang X. O-GlcNAc transferase is involved in glucocorticoid receptor-mediated transrepression. J Biol Chem. 2012；Tsuda T, Wu J , Gao E, Joyce J, Markova D, Dong H, Liu Y, Zhang H, Zou Y, Gao F, Miller T, Koch W, Ma X, Chu ML. Loss of fibulin-2 protects against progressive ventricular dysfunction after myocardial infarction. J Mol Cell Cardiol. 2012；Zhang L, Park CH, Wu J , Kim H, Liu W, Fujita T, Balasubramani M, Schreiber EM, Wang XF, Wan Y. Proteolysis of Rad17 by Cdh1\u002FAPC regulates checkpoint termination and recovery from genotoxic stress. EMBO J. 2010；Wang L, Wu J , Cao H, Chen R, Zhang N, Fu J, Gao B, Zhang J, Hou R, Tang C, Ji Q. The Correlation Between Intestinal Gonadotropin-Releasing Hormone (GnRH) and Proglucagon in Hyperlipidemic Rats and Goto-Kakizaki (GK) Rats. Endocr Pathol. 2009 (co-first author；年-2021年 陕西省自然科学基金重点项目 “ O-GlcNAc糖基化修饰IDH2对结肠癌发生和代谢重塑的影响及分子机制研究 ”（S2019-JC-ZD-0074；年 -2018 年 国家自然科学基金面上项目“线粒体 O-GlcNAc 糖基化在衰老和卡路里限制过程中对线粒体代谢调控 ” （ 81471401 ），项目负责人；年 -2011 年 教育部高等学院博士学科点专项科研基金项目（新教工基金）“ Fibulin 2 调节心脏 EMT 重塑的分子机制研 究” （ 200806981054 ），项目负责人；年 -2006 年国家自然科基金青年项目“ NSAIDs 肿瘤预防途径的非 COX-2 依赖性 途径”（ NSFC No. 30300410 ），项目负责人","【产业方向】生物医药","陕西",64,false,"https:\u002F\u002Fgr.xjtu.edu.cn\u002Fjing_wu\u002Fzh_CN\u002Findex.htm",true,[23,26,29,32,35,38,41,44],{"code":24,"name":25},"CH-10","生物医药",{"code":27,"name":28},"CH-28","交通",{"code":30,"name":31},"CH-33","人工智能",{"code":33,"name":34},"GB-27","医药制造业",{"code":36,"name":37},"GB-67","资本市场服务",{"code":39,"name":40},"GB-73","研究和试验发展",{"code":42,"name":43},"GB-83","教育",{"code":45,"name":46},"SEI-04","生物产业",[25,28,31,34,37,40,43,46],1,30,{"schools":51},297]