[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"tags-groups":3,"chains-groupcat":4,"experts-list":5,"experts-coverage":178},[],[],{"list":6,"total":175,"page":176,"pageSize":177,"totalPages":176},[7,39,52,71,84,96,114,130,150,161],{"id":8,"name":9,"orgName":10,"school":11,"gender":12,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":15,"intro":16,"province":17,"completeness":18,"avatarAuthorized":19,"sourceUrl":20,"nameValid":21,"tags":22,"tagNames":38},"b63b6aa5-af4f-43dd-88f2-00ada2d733b7","丁兆军","山东大学生命科学学院","山东大学","男","教授",null,"以拟南芥、玉米和大豆等作物为材料， 综合利用细胞生物学、分子生物学、生物化学及遗传学等技术手段，研究：1）植物根的可塑性生长发育及逆境适应机理；2）大豆根瘤固氮的分子机理。主持包括国家重点研发计划，国家基金重点项目等十余项国家级课题，相关成果先后在 Molecular Plant, Science Advances, Nature Communications, EMBO Journal, Advanced Science, EMBO Reports, Cell Reports，PNAS，Plant Cell，Plant Biotechnology Journal, New Phytologist, Plant Physiology, Plant Journal 等学术主流期刊发表90多篇学术论文 ， 被引用 7800 多次，多篇为 ESI 高被引或被 F1000\u002FH1Connect 推荐，部分成果获 2020 年山东省自然科学一等奖。应邀多次在国际著名综述性期刊 Trends in Plant Science 撰写论文，其中一篇被收录于 Cell 的 “2015 聚焦中国植物科学 ” 。","【产业方向】生物医药","山东",77,false,"https:\u002F\u002Ffaculty.sdu.edu.cn\u002Fdingzhaojun\u002Fzh_CN\u002Findex.htm",true,[23,26,29,32,35],{"code":24,"name":25},"GB-27","医药制造业",{"code":27,"name":28},"GB-67","资本市场服务",{"code":30,"name":31},"GB-73","研究和试验发展",{"code":33,"name":34},"SEI-04","生物产业",{"code":36,"name":37},"CH-10","生物医药",[25,28,31,34,37],{"id":40,"name":41,"orgName":42,"school":42,"gender":14,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":43,"intro":16,"province":44,"completeness":45,"avatarAuthorized":19,"sourceUrl":46,"nameValid":21,"tags":47,"tagNames":51},"f86fe0ed-4fd8-4c72-9d30-b09c93255550","刘连新","中国科学技术大学","细胞生物学；细胞生物学；外科学；外科学","安徽",72,"http:\u002F\u002Ffaculty.ustc.edu.cn\u002FLiulianxin\u002Fzh_CN\u002Findex.htm",[48,49,50],{"code":24,"name":25},{"code":33,"name":34},{"code":36,"name":37},[25,34,37],{"id":53,"name":54,"orgName":55,"school":55,"gender":14,"title":56,"degree":14,"honor":14,"position":14,"researchDirection":57,"intro":16,"province":14,"completeness":58,"avatarAuthorized":19,"sourceUrl":59,"nameValid":21,"tags":60,"tagNames":70},"24f4614d-2f7f-4ee0-b37e-d971a91afbc7","张抒南","南京农业大学","副教授","作物生育期与氮素利用互作的分子遗传机制；根系氮素利用及根际氮循环的互作机制。旨在利用细胞生物学；分子遗传学等手段，挖掘协同调控作物生长及氮素利用的关键基因并解析调控的分子机制；明确根系与根际微生物互作参与作物氮素利用的调控机制。为培育高产氮高效的作物品种奠定理论基础",67,"http:\u002F\u002Ffaculty.njau.edu.cn\u002FZSN12\u002Fzh_CN\u002Findex.htm",[61,64,65,66,67],{"code":62,"name":63},"GB-01","农业",{"code":24,"name":25},{"code":33,"name":34},{"code":36,"name":37},{"code":68,"name":69},"CH-24","现代农业",[63,25,34,37,69],{"id":72,"name":73,"orgName":74,"school":74,"gender":14,"title":75,"degree":14,"honor":14,"position":14,"researchDirection":76,"intro":16,"province":77,"completeness":58,"avatarAuthorized":19,"sourceUrl":78,"nameValid":21,"tags":79,"tagNames":83},"5991d8f2-2ec5-402a-abba-975b72cfff7a","郭辉","中南大学","研究员","细胞生物学","湖南","http:\u002F\u002Ffaculty.csu.edu.cn\u002Fguohui\u002Fzh_CN\u002Findex.htm",[80,81,82],{"code":24,"name":25},{"code":33,"name":34},{"code":36,"name":37},[25,34,37],{"id":85,"name":86,"orgName":55,"school":55,"gender":14,"title":56,"degree":14,"honor":14,"position":14,"researchDirection":87,"intro":16,"province":14,"completeness":58,"avatarAuthorized":19,"sourceUrl":88,"nameValid":21,"tags":89,"tagNames":95},"d8633693-7866-4504-a0b8-d506ef5d0259","徐晨","植物逆境感知与信号转导；根际微生物与作物养分高效利用；有益微生物活性物质植物端受体鉴定及根际微生物与植物逆境响应互作。通过细胞生物学；抗逆作物品种及绿色高效栽培提供理论支撑","http:\u002F\u002Ffaculty.njau.edu.cn\u002Frabbitxc19\u002Fzh_CN\u002Findex.htm",[90,91,92,93,94],{"code":62,"name":63},{"code":24,"name":25},{"code":33,"name":34},{"code":36,"name":37},{"code":68,"name":69},[63,25,34,37,69],{"id":97,"name":98,"orgName":99,"school":100,"gender":14,"title":101,"degree":14,"honor":14,"position":14,"researchDirection":102,"intro":16,"province":103,"completeness":104,"avatarAuthorized":19,"sourceUrl":105,"nameValid":21,"tags":106,"tagNames":113},"412f7cb0-1f14-4dfd-a38b-2f3e62574776","张琰","西安交通大学生命科学与技术学院","西安交通大学","副研究员","相分离及复杂疾病易感变异机制解析等。 欢迎对细胞生物学、遗传学、分子生物学感兴趣的同学加入团队！ 课题组主页： https:\u002F\u002Fgr.xjtu.edu.cn\u002Fweb\u002Fyangtielin","陕西",64,"https:\u002F\u002Fgr.xjtu.edu.cn\u002Fzhangyan11\u002Fzh_CN\u002Findex.htm",[107,108,109,110],{"code":24,"name":25},{"code":33,"name":34},{"code":36,"name":37},{"code":111,"name":112},"CH-28","交通",[25,34,37,112],{"id":115,"name":116,"orgName":117,"school":100,"gender":14,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":118,"intro":16,"province":103,"completeness":104,"avatarAuthorized":19,"sourceUrl":119,"nameValid":21,"tags":120,"tagNames":129},"b7abdb8c-6017-4ceb-b6e7-c2e6519786fb","丁毅","西安交通大学基础医学院","我们实验室主要研究人出生缺陷的分子和遗传机制，包括 先天性 神经系统疾病 （Congenital anomalies of nervous system ; 如无脑畸形、露脑畸形、脑积水、神经管畸形和神经发育缺陷等 ）、 身材矮小 （Dwarfism）、 遗传 性肾病 (Genetic kidney diseases) 和 颅颌面畸形 （Craniofacial disorders） 等几种重大疾病。我们的研究策略为：从医院收集病例──全外显子测序（ WES ）以鉴定致病基因──建立致病基因的斑马鱼和小鼠敲除 \u002F 敲入模型 ── 阐明致病基因导致疾病发生的分子机制。；我们尤其关注新的分泌蛋白（潜在的生长因子或者激素）和跨膜蛋白（潜在的受体）编码基因的变异，因为它们是良好的潜在药物靶标。我们尤为感兴趣的是这些新的分泌蛋白和跨膜蛋白在一些关键信号通路（包括FGF信号通路、Insulin信号通路、WNT信号通路、HH信号通路和TGF-β信号通路等）中的功能，以及它们通过调控这些关键信号在疾病发生中的作用。；欢迎具有生物学（发育生物学、细胞生物学、分子生物学、生物化学和生理学）和基础医学背景的研究生加入我们实验室。；Publications:；(1) Huaxiang Zhao#, Pan Wang#, Yuhua Jiao#, Huimei Huang#, Min Yu, Qing He, Wenbin Huang, Xuqin Liang, Yanzhen He, Yunfei Jia , Qianying Kong, Huifang Peng, Yuxia Hou , Zhanping Ren, Yongwei Tao, Fei Huang, Hongwei Jiang, Shan Sun, Jiuxiang Lin, Chunyan Yin*, Xuechen Zhu*, Feng Chen*, Yi Ding *. HER2 deficiency causes a developmental disorder with growth retardation and craniofacial malformations. Journal of Clinical Investigation ( 2026) doi : 10.1172\u002FJCI199043. (#co-first author; * co-corresponding author )；( 2) Xiaowen Zheng#, Xuqin Liang#, Xiantao Wu#, Qing He#, Chunyan Yin, Yuhua Jiao, Yanhao Wang, Yongwei Tao, Yanzhen He, Yunfei Jia , Linping Xu, Zhanping Ren, Yuxia Hou *, Yi Ding *, Huaxiang Zhao*. Rare variants in NRSN2 cause non-syndromic orofacial cleft through dysregulation of TGF-β signaling. Genes & Diseases (accepted). (#co-first author; *co-corresponding author )；(3) Qing He#, Min Yu#, Yuhua Jiao#, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou , Zhanping Ren, Beile Lyu , Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang*, Chunyan Yin*, Huaxiang Zhao*, Yi Ding *. Exome sequencing r eveals the genetic a rchitecture of non-syndromic o rofacial c lefts and identifies BOC as a novel c ausal g ene . Advanced Science (2025): e12073 . doi : 10.1002\u002Fadvs.202412073. (#co-first author; * co-corresponding author)；(4) Huaxiang Zhao#, Qing He#, Xiantao Wu, Xuqin Liang, Yuhua Jiao, Yue Zhang, Shanying Bao, Linping Xu, Yuxia Hou*, Xuechen Zhu*, Yi Ding *. Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts. Genomics (2023) 115(3):110630. (#co-first author; * co-corresponding author )；(5) Qing He, Xingke Hao , Shanying Bao, Xiantao Wu, Linping Xu, Yuxia Hou, Yingjia Huang, Leiyuan Peng, Huimei Huang*, Yi Ding *, Huaxiang Zhao*. A392V and R945X mutations cause orofacial clefts via impairing PTCH1 function. Genomics . (2022) 114(6):110507. (* co-corresponding author )；(6) Fangfang Zhang#, Xuechen Zhu#, Pan Wang#, Qing He, Huimei Huang, Tianrui Zheng, Yongyu Li, Hong Jia , Linping Xu, Huaxiang Zhao, Gabriele Colozza , Qinghua Tao*, Edward M De Robertis *, and Yi Ding *, The cytokine FAM3B\u002FPANDER is an FGFR ligand that promotes posterior development in Xenopus . PNAS (2021 ) 118(20):e2100342118. (#co-first author; * co-corresponding author )；(7) Yi Ding #, Gabriele Colozza #, Eric A. Sosa#, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski , and Edward M. De Robertis *, Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis. PNAS (2018) 115, E9135-E9144. (#co-first author; * corresponding author )；(8) Yi Ding #, Diego Ploper #, Eric A. Sosa, Gabriele Colozza , Yuki Moriyama, Maria D. J. Benitez, Kelvin Zhang, Daria Merkurjev , and Edward M. De Robertis *, Spemann organizer transcriptome induction by early beta-catenin, Wnt , Nodal, and Siamois signals in Xenopus laevis . PNAS (2017) 114, E3081-E3090. (#co-first author; * corresponding author)；(9) Yi Ding #, Gabriele Colozza #, Kelvin Zhang, Yuki Moriyama, Diego Ploper , Eric A. Sosa, Maria D. J. Benitez, and Edward M. De Robertis *, Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula. Developmental Biology (2017) 426, 176-187. (#co-first author; * corresponding author )；(10) Yan Zhang#, Yi Ding #, Ye- Guang Chen*, Qinghua Tao*, NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling. Developmental Biology (2014) 392, 15-25. (#co-first author; * corresponding author )；(11) Yi Ding # ， Yan Zhang#, Chao Xu, Qinghua Tao*, Ye- Guang Chen*, HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation. Journal of Biological Chemistry (2013 ) 288, 8289-8298. (# co-first author; * co-corresponding author )；(12) Yan Shi#, Yi Ding #, Yun‐Ping Lei#, Xue ‐Yan Yang, Guo ‐Ming Xie , Jun Wen, Chun‐ Quan Cai , Hong Li, Ying Chen, Ting Zhang, Bai‐Lin Wu, Li Jin , Ye‐ Guang Chen*, Hong‐Yan Wang*, Identification of novel rare mutations of DACT1 in human neural tube defects. Human Mutation (2012) 33, 1450-1455. (#co-first author; * co-corresponding author)","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fdingyi1510\u002Fzh_CN\u002Findex.htm",[121,122,123,126,127,128],{"code":24,"name":25},{"code":30,"name":31},{"code":124,"name":125},"GB-84","卫生",{"code":33,"name":34},{"code":36,"name":37},{"code":111,"name":112},[25,31,125,34,37,112],{"id":131,"name":132,"orgName":99,"school":100,"gender":133,"title":56,"degree":14,"honor":14,"position":14,"researchDirection":134,"intro":16,"province":103,"completeness":104,"avatarAuthorized":19,"sourceUrl":135,"nameValid":21,"tags":136,"tagNames":149},"e5cb857f-19f2-4f6f-983e-279c78293537","吴静","女","近年来研究方向为生物化学和细胞生物学基础研究，主要从事肿瘤和衰老等疾病的发病机制、代谢调控和信号传导等基础研究，近；年所取得的研究成果已在 Cell 以及 Cell Metabolism 等国际一流杂志发表；余篇。主持国家自然科学基金面上项目、国家自然科学基金青年项目、教育部博士学科点新教工基金等资助项目，项目经费累计约 100 万元；Wu J , Liu J, Lapenta K, Desrouleaux R, Li MD, Yang X. Regulation of the urea cycle by CPS1 O-GlcNAcylation in response to dietary restriction and aging. J Mol Cell Biol. 2022；Lu X, Yang P, Zhao X, Jiang M, Hu S, Ouyang Y, Zeng L, Wu J . OGDH mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer. Exp Cell Res. 2019；Lu X, Wu N, Yang W, Sun J, Yan K, Wu J . OGDH promotes the progression of gastric cancer by regulating mitochondrial bioenergetics and Wnt\u002Fβ-catenin signal pathway. OncoTargets and Therapy. 2019；Singh J.P., K. Zhang, J. Wu , X. Yang. O-GlcNAc signaling in cancer metabolism and epigenetics. Cancer Lett. 2015；Wu J , Damon B, Sadlonova A, Whisenhunt TR, Rustgi AK, Nie YZ, Paterson AJ, Yang X. O-GlcNAc Transferase Is Critical for TLE-Mediated Repression of Canonical Wnt Signaling. J Biol Chem. 2014；Zheng A, Li H, Wang X, Feng Z, Xu J, Cao K, Zhou B, Wu J* , Liu J. Anticancer Effect of a Curcumin Derivative B63；Zhang H, Wu J , Dong H, Khan SA, Chu ML, Tsuda T. Fibulin-2 Deficiency Attenuates Angiotensin II-Induced Cardiac Hypertrophy By Reducing Transforming Growth Factor- β Signaling. Clin Sci (Lond). 2014 (Co-first author；Ruan H.B., M.O. Dietrich, Z.W. Liu, M.D. Li, J.P. Singh, K. Qian, K. Zhang, M.R. Zimmer, J. Wu , T.L. Horvath, X. Yang. O-GlcNAc transferase-controlled AgRP neurons suppress browning of white fat. Cell. 2014；Ruan H.B., J.P. Singh, M.D. Li, J. Wu , X. Yang. Cracking the O-GlcNAc code in metabolism. Trends Endocrinol. Metab. 2013；Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J , Yates JR 3rd, Yang X. O-GlcNAc transferase\u002Fhost cell factor C1 complex regulates gluconeogenesis by modulating PGC-1 α stability. Cell Metab. 2012；Li MD, Ruan HB, Singh JP, Zhao L, Zhao T, Azarhoush S, Wu J , Evans RM, Yang X. O-GlcNAc transferase is involved in glucocorticoid receptor-mediated transrepression. J Biol Chem. 2012；Tsuda T, Wu J , Gao E, Joyce J, Markova D, Dong H, Liu Y, Zhang H, Zou Y, Gao F, Miller T, Koch W, Ma X, Chu ML. Loss of fibulin-2 protects against progressive ventricular dysfunction after myocardial infarction. J Mol Cell Cardiol. 2012；Zhang L, Park CH, Wu J , Kim H, Liu W, Fujita T, Balasubramani M, Schreiber EM, Wang XF, Wan Y. Proteolysis of Rad17 by Cdh1\u002FAPC regulates checkpoint termination and recovery from genotoxic stress. EMBO J. 2010；Wang L, Wu J , Cao H, Chen R, Zhang N, Fu J, Gao B, Zhang J, Hou R, Tang C, Ji Q. The Correlation Between Intestinal Gonadotropin-Releasing Hormone (GnRH) and Proglucagon in Hyperlipidemic Rats and Goto-Kakizaki (GK) Rats. Endocr Pathol. 2009 (co-first author；年-2021年 陕西省自然科学基金重点项目 “ O-GlcNAc糖基化修饰IDH2对结肠癌发生和代谢重塑的影响及分子机制研究 ”（S2019-JC-ZD-0074；年 -2018 年 国家自然科学基金面上项目“线粒体 O-GlcNAc 糖基化在衰老和卡路里限制过程中对线粒体代谢调控 ” （ 81471401 ），项目负责人；年 -2011 年 教育部高等学院博士学科点专项科研基金项目（新教工基金）“ Fibulin 2 调节心脏 EMT 重塑的分子机制研 究” （ 200806981054 ），项目负责人；年 -2006 年国家自然科基金青年项目“ NSAIDs 肿瘤预防途径的非 COX-2 依赖性 途径”（ NSFC No. 30300410 ），项目负责人","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fjing_wu\u002Fzh_CN\u002Findex.htm",[137,138,139,140,143,144,145,146],{"code":24,"name":25},{"code":27,"name":28},{"code":30,"name":31},{"code":141,"name":142},"GB-83","教育",{"code":33,"name":34},{"code":36,"name":37},{"code":111,"name":112},{"code":147,"name":148},"CH-33","人工智能",[25,28,31,142,34,37,112,148],{"id":151,"name":152,"orgName":74,"school":74,"gender":14,"title":56,"degree":14,"honor":14,"position":14,"researchDirection":153,"intro":16,"province":77,"completeness":104,"avatarAuthorized":19,"sourceUrl":154,"nameValid":21,"tags":155,"tagNames":160},"15a56963-d05f-4866-b58e-cacfe04792e8","章玲玲","[1] （1）肿瘤（如结直肠癌）发病机制的研究； （2）肿瘤分子诊断及新靶标的鉴定。利用光免疫疗法结合肿瘤遗传学及个体精准疗法，鉴定Akt\u002FFoxO3a的两个直接下游PUMA及SIRT6可作为结直肠癌中的潜在分子靶标。 （3）弱激光治疗神经退行性疾病。 特别在利用激光共聚焦扫描显微镜及荧光共振能量转移技术在活细胞内实时，定量，原位反映蛋白激活，相互作用，亚细胞定位等方面积累了难得的经验。首次在单个活细胞内，实时观测Akt激活全程。将生物物理、肿瘤遗传学、免疫学及细胞生物学和生物化学有机结合。","http:\u002F\u002Ffaculty.csu.edu.cn\u002Fzhanglingling\u002Fzh_CN\u002Findex.htm",[156,157,158,159],{"code":24,"name":25},{"code":30,"name":31},{"code":33,"name":34},{"code":36,"name":37},[25,31,34,37],{"id":162,"name":163,"orgName":117,"school":100,"gender":14,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":164,"intro":16,"province":103,"completeness":165,"avatarAuthorized":19,"sourceUrl":166,"nameValid":21,"tags":167,"tagNames":174},"8d3915f0-fcd5-475b-a89a-6d6cf00549b5","王洪亮","病毒为严格寄生微生物，病毒必须依赖宿主的酶、能量代谢系统及物理骨架来完成自己的生命周期，因此病毒感染过程会与宿主发生密切而又动态变化的相互作用。研究病毒与宿主的相互作用，不仅可以帮助我们了解病毒感染的规律及发现新的药物研究靶点，而且病毒也为我们研究宿主细胞的功能提供了很好的工具。；本实验室的长期目标是阐明病毒与宿主相互作用的规律及病毒导致宿主病变的机理，为了实现这一目标，我们将采用多种不同的病毒，从分子、细胞、到动物整体水平对病毒感染的分子机理开展系列研究。目前实验室的课题包括病毒复制场所的蛋白质组学研究、宿主因子在病毒感染过程中功能研究及噬菌体与细菌耐药机理研究等。；本实验室目前已建立完善的分子生物学、细胞生物学研究平台，并依托西安交通大学环境与基因相关疾病重点实验室、动物中心及附属医院，能够开展从分子，到细胞，到动物整体的基础性研究及临床相关的转化医学研究。；欢迎志同道合者加入本实验室，与本实验室合作！",59,"https:\u002F\u002Fgr.xjtu.edu.cn\u002Fhongliangwang\u002Fzh_CN\u002Findex.htm",[168,169,170,171,172,173],{"code":24,"name":25},{"code":30,"name":31},{"code":124,"name":125},{"code":33,"name":34},{"code":36,"name":37},{"code":111,"name":112},[25,31,125,34,37,112],10,1,30,{"schools":179},297]