[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"tags-groups":3,"chains-groupcat":4,"experts-list":5,"experts-coverage":50},[],[],{"list":6,"total":48,"page":48,"pageSize":49,"totalPages":48},[7],{"id":8,"name":9,"orgName":10,"school":11,"gender":12,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":15,"intro":16,"province":17,"completeness":18,"avatarAuthorized":19,"sourceUrl":20,"nameValid":21,"tags":22,"tagNames":47},"296beb6a-2c2d-4496-b1a5-e71113c036a4","许丹","西安交通大学生命科学与技术学院","西安交通大学","女","教授",null,"主要研究方向为基于多组学大数据分析的肠道微生物组（microbiome）与宿主及其免疫系统相互作用。肠道微生物通过与宿主相互作用以多种方式影响人体的营养摄入、免疫、代谢、生长发育、多种疾病发生和进程以及神经系统的功能。许丹教授围绕肠道致病菌与宿主相互作用这一主题，以志贺菌为代表的肠道致病菌的致病机理、免疫因子在其中的功能角色和可能的利用价值等方面进行了深入研究。基于前期研究成果，现已以第一作者 \u002F 通讯作者在 Nature Microbiology，Immunity 等感染和免疫顶尖期刊发表 研究 论文 十余 篇 ；获国家授权发明专利；项，陕西省科学技术二等奖（第三完成人；次。先后主持了国家自然科学基金；项、中国博士后科学基金；项，研究成果得到了国家自然科学基金委的报道和国内外学者的引用和正面评价，目前担任 SCI 杂志 Current Microbiology 编辑；多组学分析致病菌与宿主免疫之间相互作用及其机制研究；生物大数据支撑下肠道微生物组与肠道稳态及其在对抗病原体感染中的作用及其机制研究；Dan Xu , Mengyao Guo, Xin Xu, Gan Luo, Yaxin Liu, Stephen J. Bush, Chengyao Wang, Tun Xu, Wenxin Zeng, Chongbing Liao, Qingxia Wang, Wei Zhao, Wenying Zhao, Yuezhuangnan Liu, Shanshan Li, Shuangshuang Zhao, Yaming Jiu, Nathalie Sauvonnet, Wuyuan L # , Philippe J. Sansonetti # and Kai Ye # . Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11. Nature Microbiology , 2025, Feb (Cover article, 封面文章；Chongbing Liao, Qihui Liu , Gan Luo , Yinyue Luo , Dan Yao , Qingxia Wang , Jue Zhang , Yang Wu * , Jialin Jin * , Dan Xu * , Wuyuan Lu * . Human neutrophil α-defensinHNP1 interacts with bacterial OmpA to promote Acinetobacter baumannii biofilm formation. Nature Communications , 2025 (in press；Dan Xu , Chongbing Liao, Bing Zhang, W. David Tolbert, Wangxiao He, Zhijun Dai, Wei Zhang, Weirong Yuan, Marzena Pazgier, Jun Yu, Philippe J. Sansonetti, Charles L. Bevins, Yongping Shao, Wuyuan Lu. Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity , 2018 , 48；Dan Xu *, Jiu Xiao , Dazhao Jiang , Yaxin Liu , Zhuolun Gou , Jing Li , Mingyao Shi , Xinyi Wang, Yaxuan Guo , Lingyan Ma, Hong Yin, Li Guo , Chunhui Zhu, Yali Zhang *, Hui Guo *.Inhibitory effects of a water-soluble jujube polysaccharide against biofilm-forming oral pathogenic bacteria. International Journal of Biological Macromolecules , 2022, 208；Dan Xu * , Wuyuan Lu*. Defensins；Dan Xu * , Chongbing Liao, Jiu Xiao, Kun Fang, Wei Zhang, Weirong Yuan, Wuyuan Lu*. Human enteric defensin 5 promotes Shigella infection in macrophage. Infection and Immunity . 2019 , 88(1). pii；Chongbing Liao, Kun Fang, Jiu Xiao, Wei Zhang, Bing Zhang, Weirong Yuan, Wuyuan Lu * , Dan Xu * . Critical determinants of human neutrophil peptide 1 for enhancing host epithelial adhesion of Shigella flexneri. Cell Microbiol. 2019 Jun 19；Dan Xu , Wei Zhang, Bing Zhang, Chongbing Liao, Yongping Shao. Characterization of a biofilm-forming Shigella flexneri phenotype due to deficiency in Hep biosynthesis. PeerJ . 2016 Jul 14；Dan Xu , Xiaofeng Yang, Depu Wang, Jun Yu, Yili Wang. Surface display of the HPV L1 capsid protein by the autotransporter Shigella IcsA. Journal of Microbiology , 2014 , 52(1；Dan Xu , Depu Wang, Xiaofeng Yang, Meng Cao, Jun Yu, Yili Wang. Fusion of HPV L1 into Shigella surface IcsA；Dan Xu , Amir Saeed, Yili Wang, Veronique Seidel, Gunnar Sandström, Jun Yu. Natural products modulate Shigella host-cell interaction. J Medical Microbiology , 2011 , 60(11","【产业方向】生物医药","陕西",59,false,"https:\u002F\u002Fgr.xjtu.edu.cn\u002Fdan.xu\u002Fzh_CN\u002Findex.htm",true,[23,26,29,32,35,38,41,44],{"code":24,"name":25},"CH-10","生物医药",{"code":27,"name":28},"CH-28","交通",{"code":30,"name":31},"CH-35","大数据\u002F数据要素",{"code":33,"name":34},"GB-27","医药制造业",{"code":36,"name":37},"GB-67","资本市场服务",{"code":39,"name":40},"GB-73","研究和试验发展",{"code":42,"name":43},"SEI-01","新一代信息技术产业",{"code":45,"name":46},"SEI-04","生物产业",[25,28,31,34,37,40,43,46],1,30,{"schools":51},297]