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Li；M.Sc. in Agricultural Mechanization Engineering；ORCID iD orcid.org\u002F0000-0002-2959-9147；机器人触觉反馈；康复机器人；机器人脑肌电控制","【产业方向】智能制造","陕西",67,false,"https:\u002F\u002Fgr.xjtu.edu.cn\u002Fmin.li\u002Fzh_CN\u002Findex.htm",true,[399,402,405,408],{"code":400,"name":401},"CH-20","高端装备",{"code":403,"name":404},"CH-28","交通",{"code":406,"name":407},"CH-30","制造",{"code":409,"name":410},"SEI-02","高端装备制造产业",[401,404,407,410],{"id":413,"name":414,"orgName":415,"school":389,"gender":10,"title":416,"degree":10,"honor":10,"position":10,"researchDirection":417,"intro":418,"province":393,"completeness":76,"avatarAuthorized":395,"sourceUrl":419,"nameValid":397,"tags":420,"tagNames":434},"2a5c293c-1fd8-4263-a3d8-85bca9bdc0d9","李冬民","西安交通大学基础医学院","教授","（1）肥胖、非酒精性脂肪肝等代谢性疾病的发病机制及靶向治疗；；（2）糖脂代谢的表观遗传调控；；（3）肠道菌群、免疫代谢与非酒精性脂肪肝病。；代表性论文（ # 共同第一作者； * 通讯作者）：；Lu K#, He L#, Guo Z#, Li M, Cheng X, Liu S, Zhang T, Chen Q, Zhao R, Yang L, Wu X, Cheng K, Cao P, Wu L, Shahzad M, Zheng M, Jiao L, Wu Y, and Dongmin Li* . PDCD4 deficiency in hepatocytes exacerbates nonalcoholic steatohepatitis through enhanced MHC class II transactivator expression. Metabolism. 2024 Sep 27;161:156036. doi: 10.1016\u002Fj.metabol.2024.156036 （ SCI, IF= 10.8; JCR=Q1)；Zhao R#, Guo Z#, Lu K, Chen Q, Riaz F, Zhou Y, Yang L, Cheng X, Wu L, Cheng K, Feng L, Liu S, Wu X, Zheng M, Yin C, Dongmin Li*. Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression. Cell Death Dis. 2024 Oct 23;15(10):770. doi: 10.1038\u002Fs41419-024-07151-1. （ SCI, IF=8.1; JCR=Q1)；Lin Cao, Yue Zhou, Shuai Lin, Chunyan Yang, Zixuan Guan, Xiaofan Li, Shujie Yang, Tong Gao, Jiazhen Zhao, Ning Fan, Yanan Song, Dongmin Li , Xiang Li, Zhuo Li, Feng Guan*, and Zengqi Tan*. The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. J Extracell Vesicles. 2024 Sep;13(9):e12499. doi: 10.1002\u002Fjev2.12499 （ SCI, IF=15.5; JCR=Q1)；Lu K, Cheng X, He L, Li M, Chen Q, Qian C, Zhao R, Yang L, Liu F, Liu S, Zhang T, Feng L, Wu L, Wu X, Xu N, Li Y, Wang J, Han Y, Yuan H, Liu T*, Zheng M*, Lu S*, Li D*. LNCHC directly binds and regulates YBX1 stability to ameliorate metabolic dysfunction-associated steatotic liver disease progression. Liver Int. 2024 Jun 7. doi: 10.1111\u002Fliv.15975. Epub ahead of print. PMID: 38847599. （ SCI, IF= 6.0; JCR=Q1)；Lu K#, Zhou Y#, He L, Li Y, Shahzad M, Li D*. Coprococcus protects against high-fat diet-induced nonalcoholic fatty liver disease in mice. J Appl Microbiol. 2024 Jun 3;135(6):lxae125. doi: 10.1093\u002Fjambio\u002Flxae125. PMID: 38830802. （ SCI, IF= 3.2; JCR=Q2)；Lina Feng, Farooq Riaz, Kaikai Lu, Xiaona Cheng, Yanping Chen , Rong Zhao, Litao Wu, Shemin Lu and Dongmin Li* . Leucine Aminopeptidase 3:a Promising Serum Biomarker Candidate for Nonalcoholic Steatohepatitis Diagnosis. Int Immunopharmacol. 2023 Apr 12;119:110152. doi: 10.1016\u002Fj.intimp.2023.110152. （ SCI, IF= 5.714; JCR= Q1)；Zhong Y, Xiao Y, Gao J, Zheng Z, Zhang Z, Yao L*, Li D*. Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota. Nutr Metab (Lond). 2022 Nov 8;19(1):76. doi: 10.1186\u002Fs12986-022-00712-1. PMID: 36348361. （ Published ： 08 November 2022 ）（ SCI, IF= 4.127; JCR=Q3)；Qian Chen#, Jing Yi#, Fangtong Liu, Jing Li, Kaikai Lu, Xuan Wang, Fujun Zhang, Ya Li, Litao Wu, Xudong Yang, Shemin Lu and Dongmin Li*. TGF-β1 contributes to the hepatic inflammation in animal models with nonalcoholic steatohepatitis by Smad3\u002FTLR2 signaling pathway. Mol Immunol. 2022 Dec;152:129-139. doi: 10.1016\u002Fj.molimm.2022.10.014. Epub 2022 Nov 2. （ SCI, IF= 4.363; JCR=Q3)；Jun Wang, Xinrong Sun, Lianying Jiao, Zhengtao Xiao,Farooq Riaz, Yufeng Zhang, Pengfei Xu, Ruiqing Liu,Tiantian Tang, Meiqi Liu and Dongmin Li*. Clinical Characteristics and Variant Analyses of Transient Infantile Hypertriglyceridemia Related to GPD1 gene. Front Genet. 2022 Aug 16;13:916672. （ SCI, IF=4.772; JCR= Q1 ）；Lina Feng#, Yanping Chen#, Ke Xu, Yingchao Li, Farooq Riaz, Kaikai Lu, Qian Chen, Xiaojuan Du, Litao Wu, Dan Cao, Chunyan Li, Shemin Lu, Dongmin Li* . Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation inhibits cell autophagy in pathogenesis of NAFLD. Aging (Albany NY). 2022 Apr 11;14(7):3259-3275. （ SCI, IF= 5.955; JCR=Q1)；Zeyu Dong, Fangzhou He, Xiaosong Yan, Yuanming Xing, Yuyang Lei, Jie Gao, Ming He, Dongmin Li , Liang Bai, Zuyi Yuan, John Y-J. Shyy. Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced Steatosis. Cellular and Molecular Gastroenterology and Hepatology. 2022 Jan 3, 13(4):1161-1179. （ SCI, IF= 9.225, JCR=Q1)；Farooq Riaz, Qian Chen, Kaikai Lu, Ezra Kombo Osoro, Litao Wu, Lina Feng, Rong Zhao, Luyun Yang, Yimeng Zhou, Yingli He, Li Zhu, Xiaojuan Du, Muhammad Sadiq, Xudong Yang and Dongmin Li *. Inhibition of miR-188-5p alleviates Hepatic Fibrosis by significantly reducing the activation and proliferation of HSCs through PTEN\u002FPI3K\u002FAKT pathway. Journal of Cellular and Molecular Medicine(JCMM), 2021, doi.org\u002F10.1111\u002Fjcmm.16376 （ SCI, IF= 5.310; JCR=Q2)；Jing Li#, Qian Chen#, Jing Yi, Xi Lan, Kaikai Lu, Xiaojuan Du, Zizhen Guo, Yuanxu Guo, Manman Geng, Dongmin Li *and Shemin Lu*. IFN-γ Contributes to the Hepatic Inflammation in HFD-Induced Nonalcoholic Steatohepatitis by STAT1β\u002FTLR2 Signaling Pathway. Mol Immunol. 2021Jun; 134:118-128. （ SCI, IF= 4.407; JCR=Q3)；Kaikai Lu, Qian Chen, Mengda Li ， Lei He ， Farooq Riaz ， Tianyun Zhang and Dongmin Li* . Programmed Cell Death Factor 4 (PDCD4), a Novel Therapy Target for Metabolic Diseases besides Cancer. Free Radic Biol Med. 2020 Nov 1;159:150-163. （ SCI, IF=7.376; JCR=Q1 )；Kaiting Ning#, Kaikai Lu#, Qian Chen, Zizhen Guo, Xiaojuan Du, Farooq Riaz, Lina Feng, Yuping Fu, Chunyan Yin, Fujun Zhang, Litao Wu and Dongmin Li *. Epigallocatechin Gallate Protects Mice against Methionine-Choline-Deficient-Diet induced Non-alcoholic Steatohepatitis by Improving Gut Microbiota to Attenuate Hepatic Injury and Regulate Metabolism. ACS Omega 2020, 5, 33, 20800–20809 （ SCI, IF= 3.512; JCR=Q2)；Litao Wu, Juan Sun, Li Liu, Xiaojuan Du, Yan Liu, Xiaofei Yan, Ezra Kombo Osoro, Fujun Zhang, Lina Feng, Dong Liang, Yazhao Li, Qian Chen, Sha Sun, Lei Zhang, Xi Lan*, Dongmin Li* and Shemin Lu. Anti-toll-like receptor 2 antibody ameliorates hepatic injury, inflammation, fibrosis and steatosis in obesity-related metabolic disorder rats via regulating MAPK and NF-κB pathways. Int Immunopharmacol. 2020 Mar 6;82:106368. （ SCI, IF= 5.714; JCR=Q1)；Xi Lan*, Nan Wu, Litao Wu, Kai Qu, Ezra Kombo Osoro, Dongxian Guan, Xiaojuan Du, Bo Wang, Sifan Chen, Ji Miao, Juan Ren, Li Liu, Haiyun Li, Qilan Ning, Dongmin Li and Shemin Lu*. The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p, Molecular Therapy-Nucleic Acids, 2020, 20: 468-479. Mol Ther Nucleic Acids. 2020 Jun 5;20:468-479. （ SCI, IF= 8.886; JCR=Q1)；Lan X, Wu L, Wu N, Chen Q, Li Y, Du X, Wei C, Feng L, Li Y, Osoro EK, Sun M, Ning Q, Yan X, Yang X, Li D, Lu S. Long Noncoding RNA lnc-HC Regulates PPARγ-Mediated Hepatic Lipid Metabolism through miR-130b-3p. Mol Ther-Nucleic Acids. 2019 Oct 25;18:954-965. （ SCI, IF= 7.032; JCR=Q1)；Riaz F, Li D* . Non-coding RNA associated Competitive Endogenous RNA Regulatory Network: Novel Therapeutic Approach in Liver Fibrosis. Curr Gene Ther. 2019 Nov 6. 2019;19(5):305-317. （ SCI, IF= 4.391; JCR=Q3)；Sha Sun* ， Yuxuan Yang ， Dongmin Li ， Jin Zhu. Large Chiral Nanotubes Self-Assembled by DNA Bricks. J. Am. Chem. Soc. 2019, 141, 50, 19524–19528 （ SCI, IF= 14.695; JCR=Q1)；Yao Y#, Mao J#, Xu S, Zhao L, Long L, Chen L, Li D* , Lu S*. Rosmarinic acid inhibits nicotine-induced C-reactive protein generation by inhibiting NLRP3 inflammasome activation in smooth muscle cells. J Cell Physiol. 2019 Feb; 234(2):1758-1767. （ SCI, IF= 5.546; JCR=Q1)；Lan X, Yan J, Ren J, Zhong B, Li J, Li Y, Liu L, Yi J, Sun Q, Yang X, Sun J, Meng L, Zhu W, Holmdahl R, Li D* , Lu S*. A Novel Long Non-coding RNA Lnc-HC Binds hnRNPA2B1 to Regulate Expressions of Cyp7a1 and Abca1 in Hepatocytic Cholesterol Metabolism. 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