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HER2 deficiency causes a developmental disorder with growth retardation and craniofacial malformations. Journal of Clinical Investigation ( 2026) doi : 10.1172\u002FJCI199043. (#co-first author; * co-corresponding author )；( 2) Xiaowen Zheng#, Xuqin Liang#, Xiantao Wu#, Qing He#, Chunyan Yin, Yuhua Jiao, Yanhao Wang, Yongwei Tao, Yanzhen He, Yunfei Jia , Linping Xu, Zhanping Ren, Yuxia Hou *, Yi Ding *, Huaxiang Zhao*. Rare variants in NRSN2 cause non-syndromic orofacial cleft through dysregulation of TGF-β signaling. Genes & Diseases (accepted). (#co-first author; *co-corresponding author )；(3) Qing He#, Min Yu#, Yuhua Jiao#, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou , Zhanping Ren, Beile Lyu , Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang*, Chunyan Yin*, Huaxiang Zhao*, Yi Ding *. Exome sequencing r eveals the genetic a rchitecture of non-syndromic o rofacial c lefts and identifies BOC as a novel c ausal g ene . Advanced Science (2025): e12073 . doi : 10.1002\u002Fadvs.202412073. (#co-first author; * co-corresponding author)；(4) Huaxiang Zhao#, Qing He#, Xiantao Wu, Xuqin Liang, Yuhua Jiao, Yue Zhang, Shanying Bao, Linping Xu, Yuxia Hou*, Xuechen Zhu*, Yi Ding *. Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts. Genomics (2023) 115(3):110630. (#co-first author; * co-corresponding author )；(5) Qing He, Xingke Hao , Shanying Bao, Xiantao Wu, Linping Xu, Yuxia Hou, Yingjia Huang, Leiyuan Peng, Huimei Huang*, Yi Ding *, Huaxiang Zhao*. A392V and R945X mutations cause orofacial clefts via impairing PTCH1 function. Genomics . (2022) 114(6):110507. (* co-corresponding author )；(6) Fangfang Zhang#, Xuechen Zhu#, Pan Wang#, Qing He, Huimei Huang, Tianrui Zheng, Yongyu Li, Hong Jia , Linping Xu, Huaxiang Zhao, Gabriele Colozza , Qinghua Tao*, Edward M De Robertis *, and Yi Ding *, The cytokine FAM3B\u002FPANDER is an FGFR ligand that promotes posterior development in Xenopus . PNAS (2021 ) 118(20):e2100342118. (#co-first author; * co-corresponding author )；(7) Yi Ding #, Gabriele Colozza #, Eric A. Sosa#, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski , and Edward M. De Robertis *, Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis. PNAS (2018) 115, E9135-E9144. (#co-first author; * corresponding author )；(8) Yi Ding #, Diego Ploper #, Eric A. Sosa, Gabriele Colozza , Yuki Moriyama, Maria D. J. Benitez, Kelvin Zhang, Daria Merkurjev , and Edward M. De Robertis *, Spemann organizer transcriptome induction by early beta-catenin, Wnt , Nodal, and Siamois signals in Xenopus laevis . PNAS (2017) 114, E3081-E3090. (#co-first author; * corresponding author)；(9) Yi Ding #, Gabriele Colozza #, Kelvin Zhang, Yuki Moriyama, Diego Ploper , Eric A. Sosa, Maria D. J. Benitez, and Edward M. De Robertis *, Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula. Developmental Biology (2017) 426, 176-187. (#co-first author; * corresponding author )；(10) Yan Zhang#, Yi Ding #, Ye- Guang Chen*, Qinghua Tao*, NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling. Developmental Biology (2014) 392, 15-25. (#co-first author; * corresponding author )；(11) Yi Ding # ， Yan Zhang#, Chao Xu, Qinghua Tao*, Ye- Guang Chen*, HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation. Journal of Biological Chemistry (2013 ) 288, 8289-8298. (# co-first author; * co-corresponding author )；(12) Yan Shi#, Yi Ding #, Yun‐Ping Lei#, Xue ‐Yan Yang, Guo ‐Ming Xie , Jun Wen, Chun‐ Quan Cai , Hong Li, Ying Chen, Ting Zhang, Bai‐Lin Wu, Li Jin , Ye‐ Guang Chen*, Hong‐Yan Wang*, Identification of novel rare mutations of DACT1 in human neural tube defects. Human Mutation (2012) 33, 1450-1455. 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