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research aims to exploring the role of : ①S phingolipids signaling on hypertension, cardiac fibrosis and coronary plaque formation; ② Revealed the mechanistic role of stretch in altered calcium homeostasis and arrhythmia.",64,"https:\u002F\u002Fgr.xjtu.edu.cn\u002Fzhangyixjtu\u002Fzh_CN\u002Findex.htm",[24,25,26,27],[29,30,31,32],{"id":179,"name":180,"orgName":10,"school":11,"gender":14,"title":38,"degree":14,"honor":14,"position":14,"researchDirection":181,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":182,"nameValid":22,"tags":183,"tagNames":184},"87aa758d-c04b-495e-8d84-ce5ec9636c9c","杨春莲","心肌细胞缺血再灌注损伤，蛋白酶体与自噬的关系，Ubqln1","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fycl\u002Fzh_CN\u002Findex.htm",[24,25,26,27],[29,30,31,32],{"id":186,"name":187,"orgName":10,"school":11,"gender":14,"title":99,"degree":14,"honor":14,"position":14,"researchDirection":188,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":189,"nameValid":22,"tags":190,"tagNames":192},"3c562b8a-e49d-42c6-b103-627f324bc879","姚秦钰","Yao, Q ., Liu, J., Cui, Q., Jiang, T., Xie, X., Du, X., Zhao, Z., Lai, B., Xiao, L., and Wang, N. (2022) CCN1\u002FIntegrin α(5)β(1) Instigates Free Fatty Acid-Induced Hepatocyte Lipid Accumulation and Pyroptosis through NLRP3 Inflammasome Activation. Nutrients 14；Yao, Q. , Cui, Q., Liu, J., Xie, X., Jiang, T., Wang, H., Zhao, Z., Zhao, W., Du, X., Lai, B., Xiao, L., and Wang, N. (2022) Free fatty acids stabilize integrin β(1) via S-nitrosylation to promote monocyte-endothelial adhesion. J Biol Chem , 102765；Yao, Q. , Liu, J., Xiao, L., and Wang, N. (2019) Sonic hedgehog signaling instigates high-fat diet-induced insulin resistance by targeting PPARγ stability. J Biol Chem 294 , 3284-3293；Yao, Q. , Liu, J., Zhang, Z., Li, F., Zhang, C., Lai, B., Xiao, L., and Wang, N. (2018) Peroxisome proliferator-activated receptor γ (PPARγ) induces the gene expression of integrin α(V)β(5) to promote macrophage M2 polarization. J Biol Chem 293 , 16572-16582；Yao, Q. , Renault, M. A., Chapouly, C., Vandierdonck, S., Belloc, I., Jaspard-Vinassa, B., Daniel-Lamazière, J. M., Laffargue, M., Merched, A., Desgranges, C., and Gadeau, A. P. (2014) Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation. Blood 123 , 2429-2437；Liu, J., Yao, Q. , Xie, X., Cui, Q., Jiang, T., Zhao, Z., Du, X., Lai, B., Xiao, L., and Wang, N. (2022) Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism. Nutrients 14；Liu, J., Yao, Q. , Xiao, L., Ma, W., Li, F., Lai, B., and Wang, N. (2020) PPARγ induces NEDD4 gene expression to promote autophagy and insulin action. Febs j 287 , 529-545；Liu, J., Yao, Q. , Xiao, L., Li, F., Ma, W., Zhang, Z., Xie, X., Yang, C., Cui, Q., Tian, Y., Zhang, C., Lai, B., and Wang, N. (2020) APC\u002FCdh1 targets PECAM-1 for ubiquitination and degradation in endothelial cells. J Cell Physiol 235 , 2521-2531；Chapouly, C., Yao, Q. , Vandierdonck, S., Larrieu-Lahargue, F., Mariani, J. N., Gadeau, A. P., and Renault, M. A. (2016) Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy；Zhang, Z., Xie, X., Yao, Q. , Liu, J., Tian, Y., Yang, C., Xiao, L., and Wang, N. (2019) PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. Br J Pharmacol 176 , 2945-2961；Tian, Y., Yang, C., Yao, Q. , Qian, L., Liu, J., Xie, X., Ma, W., Nie, X., Lai, B., Xiao, L., and Wang, N. (2019) Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages. Front Immunol 10 , 1895；Luo, X., Jia, R., Yao, Q. , Xu, Y., Luo, Z., Luo, X., and Wang, N. (2016) Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet-fed middle-aged mice via a sirt1-dependent mechanism. Mol Nutr Food Res 60 , 871-885；Renault, M. A., Chapouly, C., Yao, Q. , Larrieu-Lahargue, F., Vandierdonck, S., Reynaud, A., Petit, M., Jaspard-Vinassa, B., Belloc, I., Traiffort, E., Ruat, M., Duplàa, C., Couffinhal, T., Desgranges, C., and Gadeau, A. P. (2013) Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival. Circ Res 112 , 762-770；Zhang, M., Zhang, Z., Xie, X., Yao, Q. , Liu, J., Lai, B., Xiao, L., and Wang, N. (2019) Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries. J Cell Physiol 234 , 4342-4351；Renault, M. A., Robbesyn, F., Chapouly, C., Yao, Q ., Vandierdonck, S., Reynaud, A., Belloc, I., Traiffort, E., Ruat, M., Desgranges, C., and Gadeau, A. P. (2013) Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice. Arterioscler Thromb Vasc Biol 33 , 2858-2866；Zhang, C., Deng, J., Liu, D., Tuo, X., Xiao, L., Lai, B., Yao, Q. , Liu, J., Yang, H., and Wang, N. (2018) Nuciferine ameliorates hepatic steatosis in high-fat diet\u002Fstreptozocin-induced diabetic mice through a PPARα\u002FPPARγ coactivator-1α pathway. Br J Pharmacol 175 , 4218-4228；Luo, X., Luo, Z., Zhang, Z., Yang, H., Lai, B., Yao, Q. , Xiao, L., and Wang, N. (2016) Homocysteine upregulates hepcidin expression through BMP6\u002FSMAD signaling pathway in hepatocytes. Biochem Biophys Res Commun 471 , 303-308；Xie, X., Yang, C., Cui, Q., Ma, W., Liu, J., Yao, Q. , Zhang, Z., Xiao, L., and Wang, N. (2019) Stachydrine Mediates Rapid Vascular Relaxation；Renault, M. A., Vandierdonck, S., Chapouly, C., Yu, Y., Qin, G., Metras, A., Couffinhal, T., Losordo, D. W., Yao, Q. , Reynaud, A., Jaspard-Vinassa, B., Belloc, I., Desgranges, C., and Gadeau, A. P. (2013) Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis. Circ Res 113 , 1148-1158","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fqinyu.yao\u002Fzh_CN\u002Findex.htm",[24,25,26,27,191],"FU-07",[29,30,31,32,193],"元宇宙",{"id":195,"name":196,"orgName":10,"school":11,"gender":14,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":197,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":198,"nameValid":22,"tags":199,"tagNames":200},"77318cdd-6c79-4261-aaeb-2b12ae8560c7","吕社民","复杂性疾病易感基因的定位与克隆 ；；慢性炎症性疾病的分子发病机理 ；；动物模型的构建和评价 。","https:\u002F\u002Fgr.xjtu.edu.cn\u002Flushemin\u002Fzh_CN\u002Findex.htm",[24,25,26,27],[29,30,31,32],{"id":202,"name":203,"orgName":10,"school":11,"gender":12,"title":99,"degree":14,"honor":14,"position":14,"researchDirection":204,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":205,"nameValid":22,"tags":206,"tagNames":207},"b4cadbe1-8065-454b-970b-3a3a030f247a","孙晨鸣","研究免疫细胞分化及功能调控的分子机制，筛选并研发肿瘤、感染等疾病的免疫治疗靶点、药物和策略，具体包括：；1）T细胞活化、分化及效应功能的分子调控信号通路；；2）单核\u002F巨噬细胞与T细胞相互作用，及其在疾病中的功能研究。","https:\u002F\u002Fgr.xjtu.edu.cn\u002F0020200132\u002Fzh_CN\u002Findex.htm",[24,44,25,26,27],[29,47,30,31,32],{"id":209,"name":210,"orgName":10,"school":11,"gender":12,"title":99,"degree":14,"honor":14,"position":14,"researchDirection":211,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":212,"nameValid":22,"tags":213,"tagNames":214},"f410c681-30fd-40a2-b0fd-c830757f38d6","赵凌宇","肿瘤细胞分子及表观遗传学调控机制；肿瘤基因治疗；神经干细胞及神经再生研究","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fzhaolingyu\u002Fzh_CN\u002Findex.htm",[24,44,25,26,27,86],[29,47,30,31,32,88],{"id":216,"name":217,"orgName":10,"school":11,"gender":218,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":219,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":220,"nameValid":22,"tags":221,"tagNames":222},"391a809a-8f61-4833-8304-dc99e4ef20f9","陈艳炯","女","Lai S, Wang J, Wang B, Wang R, Li G, Jia Y, Chen T, Chen Y. Alterations in gut microbiota affect behavioral and inflammatory responses to methamphetamine in mice. Psychopharmacology (Berl). 2022 Aug；Wang J, Lai S, Wang R, Zhou T, Dong N, Zhu L, Chen T, Zhang X, Chen Y. Dopamine D3 receptor in the nucleus accumbens alleviates neuroinflammation in a mouse model of depressive-like behavior. Brain Behav Immun. 2022 Mar；Wang J, Lai S, Li G, Zhou T, Wang B, Cao F, Chen T, Zhang X, Chen Y. Microglial activation contributes to depressive-like behavior in dopamine D3 receptor knockout mice. Brain Behav Immun. 2020 Jan；Wang B, Chen T, Xue L, Wang J, Jia Y, Li G, Ren H, Wu F, Wu M, Chen Y. Methamphetamine exacerbates neuroinflammatory response to lipopolysaccharide by activating dopamine D1-like receptors. Int Immunopharmacol. 2019 Aug；Wang B, Chen T, Li G, Jia Y, Wang J, Xue L, Chen Y. Dopamine Alters Lipopolysaccharide-Induced Nitric Oxide Production in Microglial Cells via Activation of D1-Like Receptors.；Wang J, Jia Y, Li G, Wang B, Zhou T, Zhu L, Chen T, Chen Y. The Dopamine Receptor D3 Regulates Lipopolysaccharide-Induced Depressive-Like Behavior in Mice. Int J Neuropsychopharmacol. 2018 May 1；Chen Y, Yang C, Zhu L, Li J, Guan F, Chen T. Depletion of D3 dopamine receptor affects methamphetamine-induced expression patterns of Pde4b and Atf3. Neurosci Lett. 2018 Feb 5","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fchenyanjiong\u002Fzh_CN\u002Findex.htm",[24,25,26,27],[29,30,31,32],{"id":224,"name":225,"orgName":10,"school":11,"gender":12,"title":99,"degree":14,"honor":14,"position":14,"researchDirection":226,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":227,"nameValid":22,"tags":228,"tagNames":229},"6e84b1b5-1e5f-4c76-95b0-2629fc6f99c0","张海峰","1）肿瘤病理；2）氯离子通道与肿瘤；3）氯离子通道药物筛选","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fzhf19841011\u002Fzh_CN\u002Findex.htm",[24,25,26,27],[29,30,31,32],{"id":231,"name":232,"orgName":10,"school":11,"gender":12,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":233,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":234,"nameValid":22,"tags":235,"tagNames":236},"9df20222-fbe6-4a57-bbb9-c7c922410418","刘成程","光动力疗法治疗肿瘤的体外和体内研究；光动力抗菌化学疗法治疗多重耐药菌感染的体外和体内研究；新型靶向载药系统的研发；新型多功能诊疗一体化光敏剂的构建及活性研究","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fliuchengcheng\u002Fzh_CN\u002Findex.htm",[24,44,25,26,27],[29,47,30,31,32],{"id":238,"name":239,"orgName":10,"school":11,"gender":218,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":240,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":241,"nameValid":22,"tags":242,"tagNames":243},"410cf777-38e9-4e91-9317-1b06dfa31443","孟列素","炎症的生物学机制与炎症疾病的靶向诊疗研究；以炎症的发生发展机制为核心，以生物大分子与代谢小分子为切入点，从固有免疫角度探讨 自身免疫疾病、代谢性疾病、肿瘤等慢性炎症疾病的发病机制，为疾病的诊疗提供新靶点和转化应用的研究基础。","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fmeng.liesu\u002Fzh_CN\u002Findex.htm",[24,44,25,26,27],[29,47,30,31,32],{"id":245,"name":246,"orgName":10,"school":11,"gender":218,"title":99,"degree":14,"honor":14,"position":14,"researchDirection":247,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":248,"nameValid":22,"tags":249,"tagNames":250},"f529366f-7dcd-4126-b6d4-9beb861e3a3e","陈乔依","癌症发生发展的 表观遗传机制 ，其中包括组蛋白变体；染色质结构；外泌体信号通路；非编码RNA在DNA复制；基因转录；基因组稳定性维持等过程中发挥的重要作用。 科研","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fqychen203\u002Fzh_CN\u002Findex.htm",[24,25,26,27],[29,30,31,32],{"id":252,"name":253,"orgName":254,"school":255,"gender":12,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":256,"intro":17,"province":257,"completeness":174,"avatarAuthorized":20,"sourceUrl":258,"nameValid":22,"tags":259,"tagNames":260},"1016cc90-29e0-4465-b0a3-2840412fff5d","曹永福","山东大学基础医学院","山东大学","基础医学；基础医学","山东","https:\u002F\u002Ffaculty.sdu.edu.cn\u002Fcaoyongfu\u002Fzh_CN\u002Findex.htm",[24,25,26],[29,30,31],{"id":262,"name":263,"orgName":10,"school":11,"gender":14,"title":13,"degree":14,"honor":14,"position":14,"researchDirection":264,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":265,"nameValid":22,"tags":266,"tagNames":267},"b7abdb8c-6017-4ceb-b6e7-c2e6519786fb","丁毅","我们实验室主要研究人出生缺陷的分子和遗传机制，包括 先天性 神经系统疾病 （Congenital anomalies of nervous system ; 如无脑畸形、露脑畸形、脑积水、神经管畸形和神经发育缺陷等 ）、 身材矮小 （Dwarfism）、 遗传 性肾病 (Genetic kidney diseases) 和 颅颌面畸形 （Craniofacial disorders） 等几种重大疾病。我们的研究策略为：从医院收集病例──全外显子测序（ WES ）以鉴定致病基因──建立致病基因的斑马鱼和小鼠敲除 \u002F 敲入模型 ── 阐明致病基因导致疾病发生的分子机制。；我们尤其关注新的分泌蛋白（潜在的生长因子或者激素）和跨膜蛋白（潜在的受体）编码基因的变异，因为它们是良好的潜在药物靶标。我们尤为感兴趣的是这些新的分泌蛋白和跨膜蛋白在一些关键信号通路（包括FGF信号通路、Insulin信号通路、WNT信号通路、HH信号通路和TGF-β信号通路等）中的功能，以及它们通过调控这些关键信号在疾病发生中的作用。；欢迎具有生物学（发育生物学、细胞生物学、分子生物学、生物化学和生理学）和基础医学背景的研究生加入我们实验室。；Publications:；(1) Huaxiang Zhao#, Pan Wang#, Yuhua Jiao#, Huimei Huang#, Min Yu, Qing He, Wenbin Huang, Xuqin Liang, Yanzhen He, Yunfei Jia , Qianying Kong, Huifang Peng, Yuxia Hou , Zhanping Ren, Yongwei Tao, Fei Huang, Hongwei Jiang, Shan Sun, Jiuxiang Lin, Chunyan Yin*, Xuechen Zhu*, Feng Chen*, Yi Ding *. HER2 deficiency causes a developmental disorder with growth retardation and craniofacial malformations. Journal of Clinical Investigation ( 2026) doi : 10.1172\u002FJCI199043. (#co-first author; * co-corresponding author )；( 2) Xiaowen Zheng#, Xuqin Liang#, Xiantao Wu#, Qing He#, Chunyan Yin, Yuhua Jiao, Yanhao Wang, Yongwei Tao, Yanzhen He, Yunfei Jia , Linping Xu, Zhanping Ren, Yuxia Hou *, Yi Ding *, Huaxiang Zhao*. Rare variants in NRSN2 cause non-syndromic orofacial cleft through dysregulation of TGF-β signaling. Genes & Diseases (accepted). (#co-first author; *co-corresponding author )；(3) Qing He#, Min Yu#, Yuhua Jiao#, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou , Zhanping Ren, Beile Lyu , Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang*, Chunyan Yin*, Huaxiang Zhao*, Yi Ding *. Exome sequencing r eveals the genetic a rchitecture of non-syndromic o rofacial c lefts and identifies BOC as a novel c ausal g ene . Advanced Science (2025): e12073 . doi : 10.1002\u002Fadvs.202412073. (#co-first author; * co-corresponding author)；(4) Huaxiang Zhao#, Qing He#, Xiantao Wu, Xuqin Liang, Yuhua Jiao, Yue Zhang, Shanying Bao, Linping Xu, Yuxia Hou*, Xuechen Zhu*, Yi Ding *. Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts. Genomics (2023) 115(3):110630. (#co-first author; * co-corresponding author )；(5) Qing He, Xingke Hao , Shanying Bao, Xiantao Wu, Linping Xu, Yuxia Hou, Yingjia Huang, Leiyuan Peng, Huimei Huang*, Yi Ding *, Huaxiang Zhao*. A392V and R945X mutations cause orofacial clefts via impairing PTCH1 function. Genomics . (2022) 114(6):110507. (* co-corresponding author )；(6) Fangfang Zhang#, Xuechen Zhu#, Pan Wang#, Qing He, Huimei Huang, Tianrui Zheng, Yongyu Li, Hong Jia , Linping Xu, Huaxiang Zhao, Gabriele Colozza , Qinghua Tao*, Edward M De Robertis *, and Yi Ding *, The cytokine FAM3B\u002FPANDER is an FGFR ligand that promotes posterior development in Xenopus . PNAS (2021 ) 118(20):e2100342118. (#co-first author; * co-corresponding author )；(7) Yi Ding #, Gabriele Colozza #, Eric A. Sosa#, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski , and Edward M. De Robertis *, Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis. PNAS (2018) 115, E9135-E9144. (#co-first author; * corresponding author )；(8) Yi Ding #, Diego Ploper #, Eric A. Sosa, Gabriele Colozza , Yuki Moriyama, Maria D. J. Benitez, Kelvin Zhang, Daria Merkurjev , and Edward M. De Robertis *, Spemann organizer transcriptome induction by early beta-catenin, Wnt , Nodal, and Siamois signals in Xenopus laevis . PNAS (2017) 114, E3081-E3090. (#co-first author; * corresponding author)；(9) Yi Ding #, Gabriele Colozza #, Kelvin Zhang, Yuki Moriyama, Diego Ploper , Eric A. Sosa, Maria D. J. Benitez, and Edward M. De Robertis *, Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula. Developmental Biology (2017) 426, 176-187. (#co-first author; * corresponding author )；(10) Yan Zhang#, Yi Ding #, Ye- Guang Chen*, Qinghua Tao*, NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling. Developmental Biology (2014) 392, 15-25. (#co-first author; * corresponding author )；(11) Yi Ding # ， Yan Zhang#, Chao Xu, Qinghua Tao*, Ye- Guang Chen*, HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation. Journal of Biological Chemistry (2013 ) 288, 8289-8298. (# co-first author; * co-corresponding author )；(12) Yan Shi#, Yi Ding #, Yun‐Ping Lei#, Xue ‐Yan Yang, Guo ‐Ming Xie , Jun Wen, Chun‐ Quan Cai , Hong Li, Ying Chen, Ting Zhang, Bai‐Lin Wu, Li Jin , Ye‐ Guang Chen*, Hong‐Yan Wang*, Identification of novel rare mutations of DACT1 in human neural tube defects. Human Mutation (2012) 33, 1450-1455. (#co-first author; * co-corresponding author)","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fdingyi1510\u002Fzh_CN\u002Findex.htm",[24,44,45,25,26,27],[29,47,48,30,31,32],{"id":269,"name":270,"orgName":10,"school":11,"gender":14,"title":99,"degree":14,"honor":14,"position":14,"researchDirection":271,"intro":17,"province":18,"completeness":174,"avatarAuthorized":20,"sourceUrl":272,"nameValid":22,"tags":273,"tagNames":274},"1cb26790-9eca-41d9-a823-8b61e88c732a","陈丽","情绪障碍的神经生物机制研究；青少年情绪障碍和学习记忆障碍的早期干预","https:\u002F\u002Fgr.xjtu.edu.cn\u002Fchen.li.xj\u002Fzh_CN\u002Findex.htm",[24,44,25,26,27],[29,47,30,31,32],418,1,30,14,{"schools":280},0]