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NO：V200514。该毒株含有H3亚型血凝素基因、N2亚型神经氨酸酶基因和具有在Vero细胞上高产性状流感病毒的6个内部基因。将该毒株在Vero细胞上连续传代培养，血凝滴度可保持在1024以上。该毒株可作为供体株与流行株遗传重配，或采用反向遗传学技术，将其6个内部基因与流行株2个表面蛋白基因进行基因重配，获得流行株的Vero细胞适应株，最终使用这一适应株制备Vero细胞流感疫苗或Vero细胞大流行流感疫苗。","C12N7\u002F08;C12N15\u002F85;C12N7\u002F01;A61K39\u002F145;A61P31\u002F16;C12R1\u002F93","2009.10.21#公开;2009.12.16#实质审查的生效;2011.01.12#授权","C12N7\u002F08",[],[],{"id":268,"patentNo":269,"title":270,"applicant":173,"inventors":271,"abstract":272,"ipc":273,"publishDate":13,"sourceUrl":13,"achievementId":13,"createdAt":14,"isOpenLicense":15,"licenseTerm":13,"licenseScope":13,"licenseFeeText":13,"licenseFeeNum":13,"patentType":16,"legalStatus":274,"applicationNo":269,"publicationNo":13,"mainIpc":253,"agency":13,"agent":13,"publishOrg":13,"provinceCode":13,"filingDate":13,"isRevitalized":19,"maintainYears":13,"isFunded":13,"implStatus1":13,"implStatus2":13,"willingness1":13,"willingness2":13,"feeWan":13,"intendedCity":13,"intendedCompany":13,"intendedPrice":13,"techMaturity":13,"starRating":13,"gbIndustryClass":13,"strategicClass":13,"productAdv":13,"prospect":13,"comboName":13,"batch":20,"province":21,"sourceText":22,"tags":275,"tagNames":276},"gpi_00980","CN200910094354.6","乙型流感病毒Vero细胞高产适应株及其制备和应用","廖国阳;刘泽;孙明波;李卫东;高菁霞;马磊;周健;张新文;蔡玮;姜述德","本发明提供一种乙型流感病毒Vero细胞高产适应株及其制备和应用。所述乙型流感病毒Vero细胞高产适应株命名为：B\u002FYunnan\u002F2\u002F2005va(B)，该毒株保藏号为：CGMCCNo.2931。该毒株能在Vero细胞上连续传代培养，并且血凝效价可保持在1∶512以上。经检测，该毒株为乙型流感病毒，Yamagata谱系。该毒株含有乙型流感病毒的八个基因片段，且具有Vero细胞上持续高产的特性。一方面，将该毒株接种于Vero细胞，收集培养物上清，即得乙型流感病毒疫苗，实验证实，该疫苗具有良好的免疫原性和保护效力。另一方面，该毒株也可作为供体毒株，通过自然选择压力重配或反向遗传学重配，得到流行株在Vero细胞上的适应株，从而制备出流行株Vero细胞流感疫苗。","C12N7\u002F00;C12N7\u002F08;A61K39\u002F145;A61P31\u002F16;C12N15\u002F85;C12N7\u002F01;C12R1\u002F93","2010.01.06#公开;2010.03.03#实质审查的生效;2011.08.24#授权",[],[],{"id":278,"patentNo":279,"title":280,"applicant":173,"inventors":281,"abstract":282,"ipc":283,"publishDate":13,"sourceUrl":13,"achievementId":13,"createdAt":14,"isOpenLicense":15,"licenseTerm":13,"licenseScope":13,"licenseFeeText":13,"licenseFeeNum":13,"patentType":16,"legalStatus":284,"applicationNo":279,"publicationNo":13,"mainIpc":285,"agency":13,"agent":13,"publishOrg":13,"provinceCode":13,"filingDate":13,"isRevitalized":19,"maintainYears":13,"isFunded":13,"implStatus1":13,"implStatus2":13,"willingness1":13,"willingness2":13,"feeWan":13,"intendedCity":13,"intendedCompany":13,"intendedPrice":13,"techMaturity":13,"starRating":13,"gbIndustryClass":13,"strategicClass":13,"productAdv":13,"prospect":13,"comboName":13,"batch":20,"province":21,"sourceText":22,"tags":286,"tagNames":287},"gpi_01042","CN200910094972.0","EV71型病毒抗原的检测方法","李琦涵;谢忠平;龙润乡;董承红;杨蓉;白惠珠;李华;崔萍芳;刘龙丁","本发明提供一种EV71型病毒抗原检测方法，它将待检EV71型病毒抗原、抗原阳性对照和抗原阴性对照分别加入酶标板的孔中，再在酶标板的各孔依次加入稀释度为1∶500～3000的生物素标记EV71型抗体，稀释度为1∶2000～10000的辣根过氧化物酶标记的链霉亲和素，TMB显色液A和B，最后在酶标板的各孔中加入终止液后，置于酶标仪上，在450nm波长下，用空白孔调零后检测吸光度A值，即得检测结果。本检测可从一般细胞培养病变法的3－5天缩短为数小时，在较短时间内确诊患者感染的病原体，且在基层医院和防控中心就可完成检测，能及时对症治疗和对疫情进行预防控制，是一种特异性好、灵敏度高、方便快捷的EV71病毒抗原检测方法。","G01N33\u002F569;G01N33\u002F543;G01N33\u002F52;G01N1\u002F34;C07K14\u002F085;C07K1\u002F14","2010.02.24#公开;2010.04.28#实质审查的生效;2014.04.23#授权","G01N33\u002F569",[],[],{"id":289,"patentNo":290,"title":291,"applicant":173,"inventors":292,"abstract":293,"ipc":294,"publishDate":13,"sourceUrl":13,"achievementId":13,"createdAt":14,"isOpenLicense":15,"licenseTerm":13,"licenseScope":13,"licenseFeeText":13,"licenseFeeNum":13,"patentType":16,"legalStatus":295,"applicationNo":290,"publicationNo":13,"mainIpc":264,"agency":13,"agent":13,"publishOrg":13,"provinceCode":13,"filingDate":13,"isRevitalized":19,"maintainYears":13,"isFunded":13,"implStatus1":13,"implStatus2":13,"willingness1":13,"willingness2":13,"feeWan":13,"intendedCity":13,"intendedCompany":13,"intendedPrice":13,"techMaturity":13,"starRating":13,"gbIndustryClass":13,"strategicClass":13,"productAdv":13,"prospect":13,"comboName":13,"batch":20,"province":21,"sourceText":22,"tags":296,"tagNames":297},"gpi_01665","CN201010179190.X","轮状病毒P[2]G3株和P[8]G1株在KMB17细胞上适应培养方法和免疫原性","孙茂盛;李鸿钧;易山;马应霞;张光明;吴晋元","轮状病毒P[2]G3株和P[8]G1株在KMB17细胞上适应性培养和免疫原性，属于病毒培养方法。本发明将两株轮状病毒在KMB17细胞上连续10代适应培养，使细胞病变随病毒代次逐渐增快，感染性滴度递增并稳定在较高水平。病毒滴度分别达到7.75CCID50\u002Fml及7.33CCID50\u002Fml。病毒适应KMB17细胞且基因组稳定，用复制的病毒免疫小鼠其血清中和抗体效价分别为1∶16384及1∶8192。本发明适应性培养轮状病毒P[2]G3株株和P[8]G1株可在KMB17细胞中稳定复制，所产生病毒保持了亲本毒株的基本生物学特性，且有较好免疫原性。","C12N7\u002F08;C12Q1\u002F70;C12Q1\u002F68;G01N33\u002F569","2010.12.01#公开;2011.01.12#实质审查的生效;2011.09.28#授权",[],[],{"id":299,"patentNo":300,"title":301,"applicant":215,"inventors":302,"abstract":303,"ipc":304,"publishDate":13,"sourceUrl":13,"achievementId":13,"createdAt":14,"isOpenLicense":15,"licenseTerm":13,"licenseScope":13,"licenseFeeText":13,"licenseFeeNum":13,"patentType":16,"legalStatus":305,"applicationNo":300,"publicationNo":13,"mainIpc":306,"agency":13,"agent":13,"publishOrg":13,"provinceCode":13,"filingDate":13,"isRevitalized":19,"maintainYears":13,"isFunded":13,"implStatus1":13,"implStatus2":13,"willingness1":13,"willingness2":13,"feeWan":13,"intendedCity":13,"intendedCompany":13,"int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