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二、技术优势： 1.克服抗癌药物高剂量给药造成副作用的缺点，提供了一种可低剂量给药达到抗肿瘤转移的药物组合物。 2.采用老药新用策略，将具有靶向作用的吉非替尼与高效低毒的抗肿瘤天然产物熊果酸进行联合用药，获得较为安全可靠的新型候选药物。 3. 该药物组合物包含物质的量比为10:1-5的熊果酸与吉非替尼，两者联用可以起到协同抗肿瘤转移的效果。 三、性能指标： （1）熊果酸与吉非替尼共组合可以对A549 与H1975细胞最高具有80%的抑制率，对H1650细胞具有25%的抑制率； （2）侵袭抑制能力：经组合药物处理后，A549和H1975细胞侵袭率分别为40%和36%； （3）抗粘附能力：经组合药物处理后，A549和H1975细胞粘附率分别为38%和35%； （4）抗迁移能力：经组合药物处理后，A549和H1975细胞迁移抑制率分别为68%和72%。","一． 产业现状、市场需求及应用前景 抗癌药物处于癌症治疗的前沿，在对抗各种类型的癌症中发挥着至关重要的作用。肿瘤学领域在开发新型抗癌药物方面取得了显著进展，然而，目前传统抗癌药物存在耐药性、毒副作用较多、价格昂贵、治疗效果不稳定等问题，因此需要开发更多适用的抗癌药物，天然产物熊果酸具有抗癌、保肝、抗炎、抗病毒、抗氧化等药理作用，将其与吉非替尼联合使用可达到联合抗癌作用。 二． 潜在市场规模 受生活方式变迁、环境恶化以及社会压力增大等多种客观因素的影响，全球癌症患者数量急剧增加。人们急需有效和创新的疗法，以改善患者预后，提高存活率，并增强生活质量。 三． 核心竞争力 与传统的抗癌药物相比，本专利沿用了老药新用的策略，使用熊果酸与吉非替尼组合使用，另外，熊果酸作为一种天然来源的绿色产品，原料易得且生物安全性好，总之，本产品具有制备简单，方便，生物利用度高，癌细胞抑制率高，绿色环保等独特的优势。 四． 推广社会价值 这种联合用药方案有望成为一种安全可靠的新型候选药物，为抗癌治疗带来新的希望。这种创新的治疗策略展示了潜在的治疗优势，为未来的抗癌药物研发提供了有益的思路和方向。","省级","福建省","粤港澳知识产权大数据综合服务平台·广东省知识产权保护中心",[],[],{"id":137,"patentNo":138,"title":139,"applicant":140,"inventors":141,"abstract":13,"ipc":142,"publishDate":13,"sourceUrl":13,"achievementId":13,"createdAt":117,"isOpenLicense":15,"licenseTerm":13,"licenseScope":13,"licenseFeeText":13,"licenseFeeNum":13,"patentType":13,"legalStatus":118,"applicationNo":138,"publicationNo":13,"mainIpc":13,"agency":13,"agent":13,"publishOrg":13,"provinceCode":13,"filingDate":13,"isRevitalized":18,"maintainYears":119,"isFunded":143,"implStatus1":121,"implStatus2":13,"willingness1":13,"willingness2":13,"feeWan":13,"intendedCity":144,"intendedCompany":13,"intendedPrice":124,"techMaturity":125,"starRating":145,"gbIndustryClass":146,"strategicClass":147,"productAdv":148,"prospect":148,"comboName":13,"batch":131,"province":132,"sourceText":133,"tags":149,"tagNames":150},"rv_122375","CN201720732195.8","一种具有卷收式背带的背包","黎明职业大学","彭飘林,刘昭霞","A45F3\u002F04,A45F3\u002F08","否","不-限","四星","其他日用杂品制造","新型高强塑汽车钢加工,钛及钛合金制造,聚氨酯材料及原料制造,特种玻璃制造,能源用钢加工,镁及镁合金制造,氟硅合成材料制造,特种陶瓷制造,高性能纤维及制品制造,能源油气钻采集储用钢加工,稀有金属材料制造,高性能橡胶及弹性体制造,人工晶体制造,高性能纤维复合材料制造,3D打印用材料制造,石化压力容器用钢加工,贵金属材料制造,高性能膜材料制造,新型建筑材料制造,其他高性能复合材料制造,超导材料制造,新材料研发与设计服务,先进制造基础零部件用钢制造,高技术船舶及海洋工程用钢加工,铝及铝合金制造,先进轨道交通用钢加工,铜及铜合金制造,高性能塑料及树脂制造,新一代功能复合化建筑用钢加工,稀土新材料制造,专用化学品及材料制造,矿物功能材料制造,智能、仿生与超材料制造,质检技术服务,高性能工程、矿山及农业机械用钢加工,硬质合金及制品制造,新型功能涂层材料制造,纳米材料制造,科技推广和应用服务,其他有色金属材料制造,生物基合成材料制造,生物医用材料制造,生命基高分子材料及功能化合物制造,液态金属制造,高品质不锈钢及耐蚀合金加工,其他化工新材料制造,其他先进钢铁材料制造,先进钢铁材料制品制造","本实用新型公开一种具有卷收式背带的背包，包括背包本体以及设于所述背包本体上的背带，所述背包本体中设有卷收装置，所述卷收装置包括卷轴，所述背带的一端与所述卷轴连接。与现有技术相比，本实用新型通过设置所述卷收装置，相较于现有背包卡扣式的调节方式更加方便便捷；通过设置所述隔离体，让背包和人体之间产生隔离空间，有利于透气，提升背包的使用体验；另外，通过设置所述减震软垫和弹性气囊，减小背带对人体的压迫。",[],[],{"id":152,"patentNo":153,"title":154,"applicant":155,"inventors":156,"abstract":13,"ipc":157,"publishDate":13,"sourceUrl":13,"achievementId":13,"createdAt":117,"isOpenLicense":15,"licenseTerm":13,"licenseScope":13,"licenseFeeText":13,"licenseFeeNum":13,"patentType":13,"legalStatus":158,"applicationNo":153,"publicationNo":13,"mainIpc":13,"agency":13,"agent":13,"publishOrg":13,"provinceCode":13,"filingDate":13,"isRevitalized":18,"maintainYears":159,"isFunded":120,"implStatus1":121,"implStatus2":13,"willingness1":160,"willingness2":160,"feeWan":161,"intendedCity":144,"intendedCompany":13,"intendedPrice":124,"techMaturity":125,"starRating":162,"gbIndustryClass":163,"strategicClass":164,"productAdv":165,"prospect":166,"comboName":13,"batch":131,"province":132,"sourceText":133,"tags":167,"tagNames":168},"rv_118649","CN201920771990.7","测量岩土体多方向水平位移的测斜装置","福州大学土木工程学院","关振长,卢文良,朱凌枫,洪晨斌,周元锦","E02D1\u002F00","有效","6","拟转让","5.00","五星","地质勘查专用设备制造","城市轨道装备制造","本实用新型涉及一种测量岩土体多方向水平位移的测斜装置，包括测斜仪探头、测斜管、刚性杆，两根测斜管的端部能通过连接套连接呈一体，测斜管的内等距间隔设置两个环槽，测斜仪探头包括的中空的金属探杆、安装在金属探杆上的定向陀螺仪、连接金属探杆的数据线缆，刚性杆包括中空的金属推杆，金属推杆的首端圆周均布有至少三个弹簧销钉，金属推杆的尾端圆周均布有至少三个方孔A，方孔A用于另一个金属推杆首端的弹簧销钉相连接，所述金属探杆尾端圆周均布至少三个方孔B，金属推杆经首端的弹簧销钉与方孔B相连接本装置结构简单，设计合理，可测量岩土体在任意待测方向上的水平位移，可满足各类岩土工程中关于岩土体水平位移测量的新需求。","本实用新型可测量岩土体在任意待测方向上的水平位移，可满足各类岩土工程中关于岩土体水平位移测量的新需求。",[],[],{"id":170,"patentNo":171,"title":172,"applicant":173,"inventors":174,"abstract":13,"ipc":175,"publishDate":13,"sourceUrl":13,"achievementId":13,"createdAt":117,"isOpenLicense":15,"licenseTerm":13,"licenseScope":13,"licenseFeeText":13,"licenseFeeNum":13,"patentType":13,"legalStatus":158,"applicationNo":171,"publicationNo":13,"mainIpc":13,"agency":13,"agent":13,"publishOrg":13,"provinceCode":13,"filingDate":13,"isRevitalized":18,"maintainYears":176,"isFunded":120,"implStatus1":121,"implStatus2":13,"willingness1":122,"willingness2":13,"feeWan":13,"intendedCity":144,"intendedCompany":13,"intendedPrice":177,"techMaturity":125,"starRating":145,"gbIndustryClass":178,"strategicClass":179,"productAdv":180,"prospect":181,"comboName":13,"batch":131,"province":132,"sourceText":133,"tags":182,"tagNames":183},"rv_120069","CN201610585022.8","一种融合深度特征和语义邻域的自动图像标注方法","福州大学计算机与大数据学院、软件学院","柯逍,周铭柯","G06K9\u002F62","9","具体面议","记录媒介复制,其他互联网服务","人工智能软件开发","本发明与现有技术相比具有以下有益效果：本发明构建通用、精简、有效的深度CNN特征提取框架，通过卷积保留有效信息、通过采样缩减特征维度，自适应提取特征，解决人工选取特征的问题；本发明还提出划分语义邻域的方法，构建视觉和语义均相近的近邻图像集来改善视觉相邻而语义不相邻的问题，并根据视觉相似度来确定每幅邻域图像的标签的贡献值，从而提升标注效果；该方法简单，实现灵活，实用性较强。","专利技术在当前人工智能、计算机视觉、机器学习等领域具有显著优势，契合了市场对于高效、便捷和安全的迫切需求。其不仅克服了现有技术在特定技术或问题方面的不足，还在关键技术点上实现了创新突破，展现了智能化、绿色化和高效化的趋势。该技术有望在人工智能一系列场景中广泛应用，推动产业升级，为企业带来经济效益的提升，同时提高产品质量和用户体验，促进社会整体福利的提升。推广该技术不仅有助于增强企业的竞争力，更能够推动科技创新成果的转化和应用，实现经济社会的可持续发展。因此，专利技术具有广阔的发展前景和重要的社会价值。",[],[],{"id":185,"patentNo":186,"title":187,"applicant":188,"inventors":189,"abstract":13,"ipc":190,"publishDate":13,"sourceUrl":13,"achievementId":13,"createdAt":117,"isOpenLicense":15,"licenseTerm":13,"licenseScope":13,"licenseFeeText":13,"licenseFeeNum":13,"patentType":13,"legalStatus":158,"applicationNo":186,"publicationNo":13,"mainIpc":13,"agency":13,"agent":13,"publishOrg":13,"provinceCode":13,"filingDate":13,"isRevitalized":18,"maintainYears":191,"isFunded":120,"implStatus1":121,"implStatus2":13,"willingness1":12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本实用新型公开一种数据线可伸缩的鼠标，其包括：鼠标本体和与鼠标本体相连的数据线，鼠标本体内具有空腔，空腔内设有固定杆，固定杆外设有能够绕其转动的转动管，转动管与固定杆之间设有弹性件，鼠标本体设有供数据线通过并通往空腔的通孔，数据线的中部与转动管相连接，数据线具有USB接口的一端伸出通孔，数据线的另一端与鼠标本体相连，鼠标本体设有将数据线夹住的夹持结构。","本实用新型在于针对现有技术的上述不足，提出一种操作简单、收纳快速、稳定性高的数据线可伸缩的鼠标，操作简单、收纳快速、稳定性高。",[],[],{"id":310,"patentNo":311,"title":312,"applicant":140,"inventors":313,"abstract":13,"ipc":314,"publishDate":13,"sourceUrl":13,"achievementId":13,"createdAt":117,"isOpenLicense":15,"licenseTerm":13,"licenseScope":13,"licenseFeeText":13,"licenseFeeNum":13,"patentType":13,"legalStatus":158,"applicationNo":311,"publicationNo":13,"mainIpc":13,"agency":13,"agent":13,"publishOrg":13,"provinceCode":13,"filingDate":13,"isRevitalized":18,"maintainYears":159,"isFunded":120,"implStatus1":121,"implStatus2":13,"willingness1":160,"willingness2":13,"feeWan":315,"intendedCity":13,"intendedCompany":13,"intendedPrice":124,"techMaturity":125,"starRating":145,"gbIndustryClass":316,"strategicClass":317,"productAdv":318,"prospect":319,"comboName":13,"batch":131,"province":132,"sourceText":133,"tags":320,"tagNames":321},"rv_118695","CN201822133290.3","带锁定机构的滑块式打捞器","王金伟,程永强","E21B31\u002F20,E21B31\u002F12","0.60","矿山机械制造","轨道交通相关服务,其他海洋相关设备与产品制造,海洋环境监测与探测装备制造,智能关键基础零部件制造,卫星应用服务,城市轨道装备制造,海洋工程装备制造,智能制造相关服务,其他航天器及运载火箭制造,其他轨道交通装备制造,深海石油钻探设备制造,智能测控装备制造,其他航空装备制造及相关服务,卫星装备制造,其他智能设备制造,卫星应用技术设备制造,铁路高端装备制造,机器人与增材设备制造,重大成套设备制造,航空器装备制造,海洋工程建筑及相关服务","本实用新型涉及带锁定机构的滑块式打捞器，包括打捞器本体、导向滑块以及锁定机构，锁定机构设置于导向滑块远离中心管内壁的一端，通过锁定机构使得打捞器在提拉钻具向上运动时，导向滑块调紧导向滑块锁紧中心管的力度，在打捞器进行提升过程中，锁定机构能够进行动作，调整打捞器的锁紧程度，在打捞作业完成后，可以通过电机驱动锁定机构动作，达到回收打捞器的目的。","本实用新型涉及钻具打捞技术领域，具体涉及一种带锁定机构的滑块式打捞器。与现有技术相比，本实用新型具备的技术效果为： a、打捞上提过程中，利用锁定机构将打捞器锁定于中心管内，保证打捞安全； b、打捞完毕后，利用电机驱动锁定机构解锁，方便打捞器回收，进行下一次打捞动作； c、打捞过程中，使用椭形转块作为锁定机构，利用椭圆结构外形来达到解锁和锁定的目的，结构简单、新颖； d、锁定机构结合椭形转块椭圆外形以及弹簧共同作用，从而实现解锁、锁定运行自如。",[],[],{"id":323,"patentNo":324,"title":325,"applicant":326,"inventors":327,"abstract":13,"ipc":328,"publishDate":13,"sourceUrl":13,"achievementId":13,"createdAt":117,"isOpenLicense":15,"licenseTerm":13,"licenseScope":13,"licenseFeeText":13,"licenseFeeNum":13,"patentType":13,"legalStatus":118,"applicationNo":324,"publicationNo":13,"mainIpc":13,"agency":13,"agent":13,"publishOrg":13,"provinceCode":13,"filingDate":13,"isRevitalized":18,"maintainYears":119,"isFunded":120,"implStatus1":121,"implStatus2":13,"willingness1":160,"willingness2":13,"feeWan":13,"intendedCity":13,"intendedCompany":13,"intendedPrice":124,"techMaturity":125,"starRating":145,"gbIndustryClass":329,"strategicClass":330,"productAdv":331,"prospect":332,"comboName":13,"batch":131,"province":132,"sourceText":133,"tags":333,"tagNames":334},"rv_118759","CN201921317897.5","可进行智能监测的高压储气库加固模拟试验装置","福建理工大学电子电气与物理学院","王健华","B65G5\u002F00,G01D21\u002F02,G05D15\u002F01","其他物料搬运设备制造,工业自动控制系统装置制造,绘图、计算及测量仪器制造","新型电子元器件及设备制造,人工智能系统服务,智能测控装备制造","创新性强 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